Literature DB >> 16574036

Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT).

Rainer Freynhagen1, Ralf Baron, Thomas Tölle, Edgar Stemmler, Ulrich Gockel, Markus Stevens, Christoph Maier.   

Abstract

OBJECTIVE: Chronic back pain is characterized by a combination of neuropathic and nociceptive mechanisms of pain generation. The prevalence of the neuropathic pain component is unknown. Thus, in the context of an explorative study, we aimed to determine the prevalence of signs and symptoms indicating neuropathic pain in adult patients treated by orthopaedists. We also aimed to assess the usefulness of handheld computers (PDAs) in data collection.
METHODS: Prospective epidemiological study in 18 orthopaedic practices or centres throughout Germany. Physician and patient questionnaires (paper/pencil or on handheld computers, PDAs) for patients with back pain of at least 3 months in duration were applied, as well as the von Korff score to assess pain intensity (visual analogue scale, VAS; 0 = no pain, 10 = worst possible pain) and pain characteristics, the Hannover Functional Ability Questionnaire (FFbH-R), and if patients agreed to provide information, the short-form Patient Health Questionnaire (PHQ-D) for depression.
RESULTS: For 717 patients, both patient and physician questionnaires were available. Mean patient age was 56 years; pain was predominantly located in the low back (87%). Median current pain intensity on the VAS was 5.0. Confirmed key signs and symptoms indicated neuropathic pain was frequent, e.g. radicular pain radiating beyond the knee towards the foot (40.0%), positive Lasegue sign (18.4%), or absent patellar reflex (17.3%). A third of all patients (33.5%) had >or=3 characteristic signs for neuropathic pain. Patient functionality was severely reduced (median 43.3%). There were no relevant differences in outcomes between patients using the paper/pencil method (47%) versus those preferring PDAs (53%).
CONCLUSION: Screening for neuropathic pain in this setting is feasible with simple questionnaires and scales on PDAs. Neuropathic pain is a major contributor to chronic back pain and a frequent component in patients seen by orthopaedists. At least one third of all patients should undergo additional diagnostic measures to confirm the cause of neuropathic pain.

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Year:  2006        PMID: 16574036     DOI: 10.1185/030079906X89874

Source DB:  PubMed          Journal:  Curr Med Res Opin        ISSN: 0300-7995            Impact factor:   2.580


  50 in total

1.  Pharmacological management of chronic low back pain in older patients: a randomized controlled trial of the effect of pregabalin and opioid administration.

Authors:  Yoshihito Sakai; Kenyu Ito; Tetsuro Hida; Sadayuki Ito; Atsushi Harada
Journal:  Eur Spine J       Date:  2015-02-15       Impact factor: 3.134

Review 2.  [Practice-oriented pain therapy in dermatology : Concept with special emphasis on pain quality].

Authors:  P Bialas; W Hubner; T Vogt; T Volk; C S L Müller
Journal:  Hautarzt       Date:  2018-01       Impact factor: 0.751

3.  Neuropathic pain in ankylosing spondylitis: a meta-analysis.

Authors:  T W Kim; S M Son; J S Lee
Journal:  Z Rheumatol       Date:  2020-02       Impact factor: 1.372

4.  Outcomes differ between subgroups of patients with low back and leg pain following neural manual therapy: a prospective cohort study.

Authors:  Axel Schäfer; Toby Hall; Gerd Müller; Kathryn Briffa
Journal:  Eur Spine J       Date:  2010-12-01       Impact factor: 3.134

5.  The prevalence of neuropathic pain: clinical evaluation compared with screening tools in a community population.

Authors:  Barbara P Yawn; Peter C Wollan; Toby N Weingarten; James C Watson; W Michael Hooten; L Joseph Melton
Journal:  Pain Med       Date:  2009-03-17       Impact factor: 3.750

6.  Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.

Authors:  Antonio Gatti; Alessandro Fabrizio Sabato; Annalisa Carucci; Laura Bertini; Massimo Mammucari; Roberto Occhioni
Journal:  Clin Drug Investig       Date:  2009       Impact factor: 2.859

Review 7.  The evaluation of neuropathic components in low back pain.

Authors:  Rainer Freynhagen; Ralf Baron
Journal:  Curr Pain Headache Rep       Date:  2009-06

Review 8.  [Symptoms and pathophysiological mechanisms of neuropathic pain syndromes].

Authors:  S Lanz; C Maihöfner
Journal:  Nervenarzt       Date:  2009-04       Impact factor: 1.214

Review 9.  Chronic low back pain: pharmacological, interventional and surgical strategies.

Authors:  Bart Morlion
Journal:  Nat Rev Neurol       Date:  2013-07-02       Impact factor: 42.937

10.  Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain.

Authors:  Carlo Luca Romanò; Delia Romanò; Cristina Bonora; Giuseppe Mineo
Journal:  J Orthop Traumatol       Date:  2009-11-18
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