N H C Salmon Hillbertz1, G Andersson. 1. Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Biomedical centre, Box 597, S-751 24 Uppsala, Sweden.
Abstract
OBJECTIVES: To define the mode of inheritance of the dorsal ridge and investigate if the ridge predisposes to the congenital abnormality dermoid sinus in the Rhodesian ridgeback. METHODS: Segregation analysis was performed, including 87 litters (n=803) produced in Sweden between 1981 and 2002. Data were corrected to avoid bias in the segregation ratio. Chi-squared analysis was performed including 402 litters (n=3598) for the evaluation of a possible genetic correlation between the ridge and dermoid sinus. RESULTS: The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus. The frequency of ridgeless offspring in the Swedish Rhodesian ridgeback population is estimated to be 5.6 per cent. CLINICAL SIGNIFICANCE: Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoid sinus.
OBJECTIVES: To define the mode of inheritance of the dorsal ridge and investigate if the ridge predisposes to the congenital abnormality dermoid sinus in the Rhodesian ridgeback. METHODS: Segregation analysis was performed, including 87 litters (n=803) produced in Sweden between 1981 and 2002. Data were corrected to avoid bias in the segregation ratio. Chi-squared analysis was performed including 402 litters (n=3598) for the evaluation of a possible genetic correlation between the ridge and dermoid sinus. RESULTS: The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus. The frequency of ridgeless offspring in the Swedish Rhodesian ridgeback population is estimated to be 5.6 per cent. CLINICAL SIGNIFICANCE: Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoid sinus.
Authors: Franziska Wielaender; Riika Sarviaho; Fiona James; Marjo K Hytönen; Miguel A Cortez; Gerhard Kluger; Lotta L E Koskinen; Meharji Arumilli; Marion Kornberg; Andrea Bathen-Noethen; Andrea Tipold; Kai Rentmeister; Sofie F M Bhatti; Velia Hülsmeyer; Irene C Boettcher; Carina Tästensen; Thomas Flegel; Elisabeth Dietschi; Tosso Leeb; Kaspar Matiasek; Andrea Fischer; Hannes Lohi Journal: Proc Natl Acad Sci U S A Date: 2017-02-21 Impact factor: 11.205