Literature DB >> 16571183

The Women's Health Initiative. What is on trial: nutrition and chronic disease? Or misinterpreted science, media havoc and the sound of silence from peers?

Agneta Yngve1, Leif Hambraeus, Lauren Lissner, Lluis Serra Majem, Maria Daniel Vaz de Almeida, Christina Berg, Roger Hughes, Geoffrey Cannon, Inga Thorsdottir, John Kearney, Jan-Ake Gustafsson, Joseph Rafter, Ibrahim Elmadfa, Nick Kennedy.   

Abstract

The first results of the Women's Health Initiative dietary intervention trial were published in the USA in February. This is a colossal intervention designed to see if diets lower in fat and higher in fruits, vegetables and grains than is usual in high-income countries reduce the incidence of breast cancer, colorectal cancer, heart disease and other chronic diseases, in women aged 50-79 years. As interpreted by US government media releases, the results were unimpressive. As interpreted by a global media blitz, the results indicate that food and nutrition has little or nothing to do with health and disease. But the trial was in key respects not reaching its aims, was methodologically controversial, and in any case has not produced the reported null results. What should the public health nutrition profession do about such messes?

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Year:  2006        PMID: 16571183     DOI: 10.1079/phn2006952

Source DB:  PubMed          Journal:  Public Health Nutr        ISSN: 1368-9800            Impact factor:   4.022


  9 in total

Review 1.  Reduced or modified dietary fat for preventing cardiovascular disease.

Authors:  Lee Hooper; Carolyn D Summerbell; Rachel Thompson; Deirdre Sills; Felicia G Roberts; Helen J Moore; George Davey Smith
Journal:  Cochrane Database Syst Rev       Date:  2012-05-16

Review 2.  Considering the value of dietary assessment data in informing nutrition-related health policy.

Authors:  James R Hébert; Thomas G Hurley; Susan E Steck; Donald R Miller; Fred K Tabung; Karen E Peterson; Lawrence H Kushi; Edward A Frongillo
Journal:  Adv Nutr       Date:  2014-07-14       Impact factor: 8.701

3.  Perspective: Randomized Controlled Trials Are Not a Panacea for Diet-Related Research.

Authors:  James R Hébert; Edward A Frongillo; Swann A Adams; Gabrielle M Turner-McGrievy; Thomas G Hurley; Donald R Miller; Ira S Ockene
Journal:  Adv Nutr       Date:  2016-05-16       Impact factor: 8.701

4.  Perspective: Limiting Dependence on Nonrandomized Studies and Improving Randomized Trials in Human Nutrition Research: Why and How.

Authors:  John F Trepanowski; John P A Ioannidis
Journal:  Adv Nutr       Date:  2018-07-01       Impact factor: 8.701

5.  A Historical Perspective of the Understanding of the Link between Diet and Coronary Heart Disease.

Authors:  Agneta Yngve
Journal:  Am J Lifestyle Med       Date:  2009

Review 6.  Reduced or modified dietary fat for preventing cardiovascular disease.

Authors:  Lee Hooper; Carolyn D Summerbell; Rachel Thompson; Deirdre Sills; Felicia G Roberts; Helen Moore; George Davey Smith
Journal:  Cochrane Database Syst Rev       Date:  2011-07-06

7.  Reduction in saturated fat intake for cardiovascular disease.

Authors:  Lee Hooper; Nicole Martin; Oluseyi F Jimoh; Christian Kirk; Eve Foster; Asmaa S Abdelhamid
Journal:  Cochrane Database Syst Rev       Date:  2020-08-21

8.  Reduction in saturated fat intake for cardiovascular disease.

Authors:  Lee Hooper; Nicole Martin; Oluseyi F Jimoh; Christian Kirk; Eve Foster; Asmaa S Abdelhamid
Journal:  Cochrane Database Syst Rev       Date:  2020-05-19

9.  A high diet quality is associated with lower incidence of cardiovascular events in the Malmö diet and cancer cohort.

Authors:  Joanna Hlebowicz; Isabel Drake; Bo Gullberg; Emily Sonestedt; Peter Wallström; Margaretha Persson; Jan Nilsson; Bo Hedblad; Elisabet Wirfält
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240

  9 in total

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