Literature DB >> 16569886

Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.

Parmjeet Randhawa1, Noush Afarin Farasati, Ron Shapiro, Karl Y Hostetler.   

Abstract

Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index.

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Year:  2006        PMID： 16569886      PMCID： PMC1426942          DOI： 10.1128/AAC.50.4.1564-1566.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Persistence of DNA in cell cultures may jeopardize the analysis of human herpesvirus 6 dynamics by means of real-time PCR.

Authors:  Pascale Bonnafous; Agnès Gautheret-Dejean; David Boutolleau; Delphine Caïola; Henri Agut
Journal:  J Virol Methods       Date:  2005-01-28       Impact factor: 2.014

2.  Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system.

Authors:  Noush Afarin Farasati; Ron Shapiro; Abhay Vats; Parmjeet Randhawa
Journal:  Transplantation       Date:  2005-01-15       Impact factor: 4.939

3.  Quantitation of DNA of polyomaviruses BK and JC in human kidneys.

Authors:  Parmjeet Randhawa; Ron Shapiro; Abhay Vats
Journal:  J Infect Dis       Date:  2005-06-22       Impact factor: 5.226

4.  In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.

Authors:  Earl R Kern; Nicole L Kushner; Caroll B Hartline; Stephanie L Williams-Aziz; Emma A Harden; Shaoman Zhou; Jiri Zemlicka; Mark N Prichard
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.

Authors:  Caroll B Hartline; Kortney M Gustin; William B Wan; Stephanie L Ciesla; James R Beadle; Karl Y Hostetler; Earl R Kern
Journal:  J Infect Dis       Date:  2004-12-29       Impact factor: 5.226

6.  Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.

Authors:  William B Wan; James R Beadle; Caroll Hartline; Earl R Kern; Stephanie L Ciesla; Nadejda Valiaeva; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

7.  Polyomavirus BK nephropathy in a kidney transplant recipient: critical issues of diagnosis and management.

Authors:  M Mayr; V Nickeleit; H H Hirsch; M Dickenmann; M J Mihatsch; J Steiger
Journal:  Am J Kidney Dis       Date:  2001-09       Impact factor: 8.860

8.  Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.

Authors:  Stephanie L Williams-Aziz; Caroll B Hartline; Emma A Harden; Shannon L Daily; Mark N Prichard; Nicole L Kushner; James R Beadle; W Brad Wan; Karl Y Hostetler; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

9.  Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients.

Authors:  K C Cundy; B G Petty; J Flaherty; P E Fisher; M A Polis; M Wachsman; P S Lietman; J P Lalezari; M J Hitchcock; H S Jaffe
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

10.  Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.

Authors:  H T Ho; K L Woods; J J Bronson; H De Boeck; J C Martin; M J Hitchcock
Journal:  Mol Pharmacol       Date:  1992-01       Impact factor: 4.436
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  30 in total

Review 1.  Prodrug strategies in ocular drug delivery.

Authors:  Megha Barot; Mahuya Bagui; Mitan R Gokulgandhi; Ashim K Mitra
Journal:  Med Chem       Date:  2012-07       Impact factor: 2.745

Review 2.  The search for new therapies for human cytomegalovirus infections.

Authors:  Mark N Prichard; Earl R Kern
Journal:  Virus Res       Date:  2010-11-21       Impact factor: 3.303

Review 3.  Polyomavirus BK infection in blood and marrow transplant recipients.

Authors:  L K Dropulic; R J Jones
Journal:  Bone Marrow Transplant       Date:  2007-10-22       Impact factor: 5.483

4.  Advances in the Development of Therapeutics for Cytomegalovirus Infections.

Authors:  Edward Acosta; Terry Bowlin; Jennifer Brooks; Lillian Chiang; Islam Hussein; David Kimberlin; Lawrence M Kauvar; Randi Leavitt; Mark Prichard; Richard Whitley
Journal:  J Infect Dis       Date:  2020-03-05       Impact factor: 5.226

5.  Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug.

Authors:  Haiyan Wang; Jay Chhablani; William R Freeman; James R Beadle; Karl Y Hostetler; Kathrin Hartmann; Laura Conner; Kathy A Aldern; Lindsey Pearson; Lingyun Cheng
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-12-09       Impact factor: 4.799

6.  Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Authors:  Mark N Prichard; Debra C Quenelle; Caroll B Hartline; Emma A Harden; Geraldine Jefferson; Samuel L Frederick; Shannon L Daily; Richard J Whitley; Kamal N Tiwari; Joseph A Maddry; John A Secrist; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

7.  Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

Authors:  Mark N Prichard; Caroll B Hartline; Emma A Harden; Shannon L Daily; James R Beadle; Nadejda Valiaeva; Earl R Kern; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2008-10-13       Impact factor: 5.191

8.  Anti-BK virus activity of nucleoside analogs.

Authors:  Parmjeet Randhawa; Jiri Zemlicka; Andreas Sauerbrei; Chris Meier; Karl Y Hostetler; James R Beadle; Noush Afarin Farasati; Yuchen Huang; Matthews Bradley
Journal:  Antimicrob Agents Chemother       Date:  2008-02-19       Impact factor: 5.191

9.  Life-threatening adenovirus infections in the setting of the immunocompromised allogeneic stem cell transplant patients.

Authors:  Cedar J Fowler; Jennifer Dunlap; Darcy Troyer; Peter Stenzel; Elliot Epner; Richard T Maziarz
Journal:  Adv Hematol       Date:  2010-06-16

10.  BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.

Authors:  Parmjeet Randhawa; Noush Afarin Farasati; Yuchen Huang
Journal:  Antimicrob Agents Chemother       Date:  2007-09-24       Impact factor: 5.191
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