Literature DB >> 16569877

Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon.

Andrea Kreidenweiss1, Benjamin Mordmüller, Sanjeev Krishna, Peter G Kremsner.   

Abstract

OZ277 is a newly developed, fully synthetic endoperoxide antimalarial that we tested against field isolates from Gabon. A comparison of activities of OZ277 with artesunate, mefloquine, and chloroquine showed OZ277 to be highly active against all parasite isolates. Artesunate and mefloquine also showed potent antiparasitic activity, but all isolates were chloroquine resistant.

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Year:  2006        PMID： 16569877      PMCID： PMC1426938          DOI： 10.1128/AAC.50.4.1535-1537.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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