Literature DB >> 16569373

Transforming growth factor-beta: recent advances on its role in immune tolerance.

Martin A Kriegel1, Ming O Li, Shomyseh Sanjabi, Yisong Y Wan, Richard A Flavell.   

Abstract

Transforming growth factor-beta (TGF-beta) is a key regulator of immune tolerance. In this paper, we will focus on T cells and natural killer (NK) cells, which are directly regulated by TGF-beta in vivo. TGF-beta controls T-cell activation and differentiation, and is involved in the suppressive function and generation of regulatory T cells. Recently, TGF-beta has also been shown to directly inhibit NK cell activity. These studies demonstrate that TGF-beta utilizes multiple mechanisms to ensure immune tolerance, which is critical in a variety of autoimmune and inflammatory disorders. We will also discuss recent advances on the role of TGF-beta in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus.

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Year:  2006        PMID： 16569373     DOI： 10.1007/s11926-006-0054-y

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  67 in total

1.  Conditional inactivation of the TGF-beta type II receptor using Cre:Lox.

Authors:  Anna Chytil; Mark A Magnuson; Christopher V E Wright; Harold L Moses
Journal:  Genesis       Date:  2002-02       Impact factor: 2.487

Review 2.  Natural regulatory T cells and self-tolerance.

Authors:  Ronald H Schwartz
Journal:  Nat Immunol       Date:  2005-04       Impact factor: 25.606

3.  TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.

Authors:  Dori A Thomas; Joan Massagué
Journal:  Cancer Cell       Date:  2005-11       Impact factor: 31.743

4.  Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

Authors:  M C Fantini; C Becker; I Tubbe; A Nikolaev; H A Lehr; P Galle; M F Neurath
Journal:  Gut       Date:  2005-09-14       Impact factor: 23.059

5.  TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.

Authors:  V L Heath; E E Murphy; C Crain; M G Tomlinson; A O'Garra
Journal:  Eur J Immunol       Date:  2000-09       Impact factor: 5.532

6.  TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet.

Authors:  Jack T Lin; Stacey L Martin; Luxi Xia; James D Gorham
Journal:  J Immunol       Date:  2005-05-15       Impact factor: 5.422

7.  Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets.

Authors:  Hee-Kap Kang; Marissa A Michaels; Beate R Berner; Syamal K Datta
Journal:  J Immunol       Date:  2005-03-15       Impact factor: 5.422

8.  TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

Authors:  Mériam Belghith; Jeffrey A Bluestone; Samia Barriot; Jérôme Mégret; Jean-François Bach; Lucienne Chatenoud
Journal:  Nat Med       Date:  2003-08-24       Impact factor: 53.440

9.  Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.

Authors:  Shannon M Pop; Carmen P Wong; Donna A Culton; Stephen H Clarke; Roland Tisch
Journal:  J Exp Med       Date:  2005-04-18       Impact factor: 14.307

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
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  17 in total

1.  A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

Authors:  Paul E Zarek; Ching-Tai Huang; Eric R Lutz; Jeanne Kowalski; Maureen R Horton; Joel Linden; Charles G Drake; Jonathan D Powell
Journal:  Blood       Date:  2007-10-01       Impact factor: 22.113

2.  Retinal laser burn disrupts immune privilege in the eye.

Authors:  Hong Qiao; Kenyatta Lucas; Joan Stein-Streilein
Journal:  Am J Pathol       Date:  2009-01-15       Impact factor: 4.307

3.  TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.

Authors:  Reena Rani; Alan G Smulian; David R Greaves; Simon P Hogan; De'Broski R Herbert
Journal:  Eur J Immunol       Date:  2011-05-27       Impact factor: 5.532

Review 4.  The role of TGF-beta signaling in dendritic cell tolerance.

Authors:  Grace E Esebanmen; William H R Langridge
Journal:  Immunol Res       Date:  2017-10       Impact factor: 2.829

5.  Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis.

Authors:  Sarah J McCaskey; Elizabeth A Rondini; Jonathan F Clinthorne; Ingeborg M Langohr; Elizabeth M Gardner; Jenifer I Fenton
Journal:  World J Gastroenterol       Date:  2012-04-07       Impact factor: 5.742

6.  TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection.

Authors:  Lisa Heitmann; Reena Rani; Lucas Dawson; Charles Perkins; Yanfen Yang; Jordan Downey; Christoph Hölscher; De'Broski R Herbert
Journal:  Am J Pathol       Date:  2012-09       Impact factor: 4.307

7.  IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis.

Authors:  De'Broski R Herbert; Tatyana Orekov; Charles Perkins; Fred D Finkelman
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

8.  Overexpression and immunosuppressive functions of transforming growth factor 1, vascular endothelial growth factor and interleukin-10 in epithelial ovarian cancer.

Authors:  Chan-Zhen Liu; Li Zhang; Xiao-Hong Chang; Ye-Xia Cheng; Hong-Yan Cheng; Xue Ye; Tian-Yun Fu; Jun Chen; Heng Cui
Journal:  Chin J Cancer Res       Date:  2012-06       Impact factor: 5.087

Review 9.  Heme oxygenase-1 as a target for TGF-β in kidney disease.

Authors:  Abolfazl Zarjou; Anupam Agarwal
Journal:  Semin Nephrol       Date:  2012-05       Impact factor: 5.299

10.  Differential requirement of PKC-theta in the development and function of natural regulatory T cells.

Authors:  Sonal Gupta; Santhakumar Manicassamy; Chenthamarakshan Vasu; Anvita Kumar; Weirong Shang; Zuoming Sun
Journal:  Mol Immunol       Date:  2008-10-08       Impact factor: 4.407
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