Literature DB >> 28845509

The role of TGF-beta signaling in dendritic cell tolerance.

Grace E Esebanmen1,2, William H R Langridge3,4.   

Abstract

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.

Entities:  

Keywords:  Dendritic cells; Immunological tolerance; T cells; TGF-β signaling

Mesh：

Substances：

Year:  2017        PMID： 28845509     DOI： 10.1007/s12026-017-8944-9

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  75 in total

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2.  Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.

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Journal:  Sci Transl Med       Date:  2015-06-03       Impact factor: 17.956

3.  CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.

Authors:  J P Rosat; E P Grant; E M Beckman; C C Dascher; P A Sieling; D Frederique; R L Modlin; S A Porcelli; S T Furlong; M B Brenner
Journal:  J Immunol       Date:  1999-01-01       Impact factor: 5.422

4.  Human Dental Pulp Stem Cells Suppress Alloantigen-induced Immunity by Stimulating T Cells to Release Transforming Growth Factor Beta.

Authors:  Kyu Hwan Kwack; Jung Min Lee; Sang Hyuk Park; Hyeon Woo Lee
Journal:  J Endod       Date:  2016-11-18       Impact factor: 4.171

5.  TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.

Authors:  Yasmina Laouar; Terrence Town; David Jeng; Elise Tran; Yisong Wan; Vijay K Kuchroo; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-31       Impact factor: 11.205

6.  Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.

Authors:  Arunika Mukhopadhaya; Tadashi Hanafusa; Irene Jarchum; Yi-Guang Chen; Yoshiko Iwai; David V Serreze; Ralph M Steinman; Kristin V Tarbell; Teresa P DiLorenzo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-22       Impact factor: 11.205

Review 7.  Transforming growth factor-beta regulation of immune responses.

Authors:  Ming O Li; Yisong Y Wan; Shomyseh Sanjabi; Anna-Karin L Robertson; Richard A Flavell
Journal:  Annu Rev Immunol       Date:  2006       Impact factor: 28.527

8.  Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.

Authors:  François Ghiringhelli; Pierre E Puig; Stephan Roux; Arnaud Parcellier; Elise Schmitt; Eric Solary; Guido Kroemer; François Martin; Bruno Chauffert; Laurence Zitvogel
Journal:  J Exp Med       Date:  2005-09-26       Impact factor: 14.307

9.  Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

Authors:  T M Fenton; A Kelly; E E Shuttleworth; C Smedley; A Atakilit; F Powrie; S Campbell; S L Nishimura; D Sheppard; S Levison; J J Worthington; M J Lehtinen; M A Travis
Journal:  Mucosal Immunol       Date:  2016-10-26       Impact factor: 7.313

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
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  34 in total

Review 1.  Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

Authors:  Joanne E Murphy-Ullrich; Mark J Suto
Journal:  Matrix Biol       Date:  2017-12-27       Impact factor: 11.583

2.  Mesh induced fibrosis: The protective role of T regulatory cells.

Authors:  Amanda M Artsen; Matthew Rytel; Rui Liang; Gabrielle E King; Leslie Meyn; Steven D Abramowitch; Pamela A Moalli
Journal:  Acta Biomater       Date:  2019-07-19       Impact factor: 8.947

Review 3.  Overcoming TGFβ-mediated immune evasion in cancer.

Authors:  Daniele V F Tauriello; Elena Sancho; Eduard Batlle
Journal:  Nat Rev Cancer       Date:  2021-10-20       Impact factor: 60.716

4.  An Open-Label Study of the Safety and Efficacy of Tag-7 Gene-Modified Tumor Cells-Based Vaccine in Patients with Locally Advanced or Metastatic Malignant Melanoma or Renal Cell Cancer.

Authors:  Aleksei Viktorovich Novik; Anna Borisovna Danilova; Maksim Ivanovich Sluzhev; Tatiana Leonidovna Nehaeva; Sergei Sergeevich Larin; Dmitry Viktorovich Girdyuk; Svetlana Anatolevna Protsenko; Anna Igorevna Semenova; Aleksei Olegovich Danilov; Vladimir Mikhailovich Moiseyenko; Georgii Pavlovich Georgiev; Irina Aleksandrovna Baldueva
Journal:  Oncologist       Date:  2020-04-07

Review 5.  TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

Authors:  Laia Caja; Francesco Dituri; Serena Mancarella; Daniel Caballero-Diaz; Aristidis Moustakas; Gianluigi Giannelli; Isabel Fabregat
Journal:  Int J Mol Sci       Date:  2018-04-26       Impact factor: 5.923

6.  Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/Glycolytic Pathway.

Authors:  Hongyun Jiang; Siwei Zhang; Tongtong Song; Xin Guan; Ruojin Zhang; Xia Chen
Journal:  Front Pharmacol       Date:  2018-06-11       Impact factor: 5.810

7.  Immunological discrepancy in aged mice facilitates skin allograft survival.

Authors:  Wei-Chen Lee; Yu-Chao Wang; Hsiu-Ying Hsu; Pao-Yueh Hsu; Chih-Hsien Cheng; Chen-Fang Lee; Ting-Jung Wu; Kun-Ming Chan
Journal:  Aging (Albany NY)       Date:  2021-06-22       Impact factor: 5.682

8.  Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors.

Authors:  A P Freitas; B C Favoretto; P B Clissa; S C Sampaio; E L Faquim-Mauro
Journal:  J Immunol Res       Date:  2018-06-03       Impact factor: 4.818

9.  The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A.

Authors:  Iwona Adwent; Beniamin Oskar Grabarek; Marta Kojs-Mrożkiewicz; Ryszard Brus; Rafał Staszkiewicz; Andrzej Plewka; Michał Stasiowski; Anita Lyssek-Boroń
Journal:  Mediators Inflamm       Date:  2020-07-26       Impact factor: 4.711

Review 10.  Immunosenescence is both functional/adaptive and dysfunctional/maladaptive.

Authors:  T Fulop; A Larbi; K Hirokawa; A A Cohen; J M Witkowski
Journal:  Semin Immunopathol       Date:  2020-09-15       Impact factor: 11.759
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