Literature DB >> 1656872

Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.

F G Araujo1, J S Remington.   

Abstract

A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.

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Year:  1991        PMID： 1656872      PMCID： PMC245240          DOI： 10.1128/AAC.35.8.1672

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.

Authors:  D Israelski; J Remington
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-05       Impact factor: 3.267

Review 2.  Toxoplasmic encephalitis in patients with AIDS.

Authors:  D M Israelski; J S Remington
Journal:  Infect Dis Clin North Am       Date:  1988-06       Impact factor: 5.982

3.  Effect of murine interferon gamma on murine toxoplasmosis.

Authors:  R E McCabe; B J Luft; J S Remington
Journal:  J Infect Dis       Date:  1984-12       Impact factor: 5.226

4.  Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii.

Authors:  F G Araujo; D R Guptill; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

5.  Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.

Authors:  F M Gordin; G L Simon; C B Wofsy; J Mills
Journal:  Ann Intern Med       Date:  1984-04       Impact factor: 25.391
  5 in total
  7 in total

1.  High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

Authors:  Joshua B Radke; Kimberly L Carey; Subrata Shaw; Shailesh R Metkar; Carol Mulrooney; Jennifer P Gale; Joshua A Bittker; Robert Hilgraf; Eamon Comer; Stuart L Schreiber; Herbert W Virgin; Jose R Perez; L David Sibley
Journal:  ACS Infect Dis       Date:  2018-08-28       Impact factor: 5.084

2.  Treatment with interleukin 12 in combination with atovaquone or clindamycin significantly increases survival of mice with acute toxoplasmosis.

Authors:  F G Araujo; C A Hunter; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

3.  Activity of gatifloxacin alone or in combination with pyrimethamine or gamma interferon against Toxoplasma gondii.

Authors:  A A Khan; T R Slifer; F G Araujo; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

4.  The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection.

Authors:  F G Araujo; A A Khan; T L Slifer; A Bryskier; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

Review 5.  Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy.

Authors:  D H Peters; H A Friedel; D McTavish
Journal:  Drugs       Date:  1992-11       Impact factor: 9.546

6.  Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis.

Authors:  F G Araujo; P Prokocimer; T Lin; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

Review 7.  Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.

Authors:  Ildiko Rita Dunay; Kiran Gajurel; Reshika Dhakal; Oliver Liesenfeld; Jose G Montoya
Journal:  Clin Microbiol Rev       Date:  2018-09-12       Impact factor: 26.132
  7 in total

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