PURPOSE: Traumatic brain injury (TBI) causes brain dysfunction in many patients. However, some patients have severe brain dysfunction but display no abnormalities on magnetic resonance imaging (MRI). There have been some reports of hypometabolism even in such patients. The purpose of this study was to investigate the relationship between metabolic abnormality and loss of neuronal integrity in TBI patients with some symptoms but without MRI abnormalities. METHODS: The study population comprised ten patients with TBI and ten normal volunteers. All of the patients were examined at least 1 year after the injury. ( 15)O-labelled gas PET and [(11)C]flumazenil (FMZ) positron emission tomography (PET) were carried out. The cerebral metabolic rate of oxygen (CMRO(2)) and binding potential (BP) images of FMZ were calculated. Axial T2WI, T2*WI and FLAIR images were obtained. Coronal images were added in some cases. RESULTS: All of the patients had normal MRI findings, and all showed areas with abnormally low CMRO(2). Low uptake on BP images was observed in six patients (60%). No lesions that showed low uptake on BP images were without low CMRO(2). On the other hand, there were 14 lesions with low CMRO(2) but without BP abnormalities. CONCLUSION: These results indicate that there are metabolic abnormalities in TBI patients with some symptoms after brain injury but without abnormalities on MRI. Some of the hypometabolic lesions showed low BP, indicating a loss of neuronal integrity. Thus, FMZ PET may have potential to distinguish hypometabolism caused by neuronal loss from that caused by other factors.
PURPOSE:Traumatic brain injury (TBI) causes brain dysfunction in many patients. However, some patients have severe brain dysfunction but display no abnormalities on magnetic resonance imaging (MRI). There have been some reports of hypometabolism even in such patients. The purpose of this study was to investigate the relationship between metabolic abnormality and loss of neuronal integrity in TBIpatients with some symptoms but without MRI abnormalities. METHODS: The study population comprised ten patients with TBI and ten normal volunteers. All of the patients were examined at least 1 year after the injury. ( 15)O-labelled gas PET and [(11)C]flumazenil (FMZ) positron emission tomography (PET) were carried out. The cerebral metabolic rate of oxygen (CMRO(2)) and binding potential (BP) images of FMZ were calculated. Axial T2WI, T2*WI and FLAIR images were obtained. Coronal images were added in some cases. RESULTS: All of the patients had normal MRI findings, and all showed areas with abnormally low CMRO(2). Low uptake on BP images was observed in six patients (60%). No lesions that showed low uptake on BP images were without low CMRO(2). On the other hand, there were 14 lesions with low CMRO(2) but without BP abnormalities. CONCLUSION: These results indicate that there are metabolic abnormalities in TBIpatients with some symptoms after brain injury but without abnormalities on MRI. Some of the hypometabolic lesions showed low BP, indicating a loss of neuronal integrity. Thus, FMZ PET may have potential to distinguish hypometabolism caused by neuronal loss from that caused by other factors.
Authors: M Ohyama; M Senda; K Ishiwata; S Kitamura; M Mishina; K Ishii; H Toyama; K Oda; Y Katayama Journal: Ann Nucl Med Date: 1999-10 Impact factor: 2.668
Authors: H Moriwaki; M Matsumoto; K Hashikawa; N Oku; M Ishida; Y Seike; M Fujita; K Fukuchi; Y Watanabe; H Terakawa; T Uehara; T Nishimura Journal: Kaku Igaku Date: 1996-06
Authors: T Shiozaki; H Akai; M Taneda; T Hayakata; M Aoki; J Oda; H Tanaka; A Hiraide; T Shimazu; H Sugimoto Journal: J Neurotrauma Date: 2001-07 Impact factor: 5.269
Authors: Franck Amyot; David B Arciniegas; Michael P Brazaitis; Kenneth C Curley; Ramon Diaz-Arrastia; Amir Gandjbakhche; Peter Herscovitch; Sidney R Hinds; Geoffrey T Manley; Anthony Pacifico; Alexander Razumovsky; Jason Riley; Wanda Salzer; Robert Shih; James G Smirniotopoulos; Derek Stocker Journal: J Neurotrauma Date: 2015-09-30 Impact factor: 5.269
Authors: Jenny B Koenig; David Cantu; Cho Low; Mary Sommer; Farzad Noubary; Danielle Croker; Michael Whalen; Dong Kong; Chris G Dulla Journal: JCI Insight Date: 2019-04-30
Authors: Virginia F J Newcombe; Joanne G Outtrim; Doris A Chatfield; Anne Manktelow; Peter J Hutchinson; Jonathan P Coles; Guy B Williams; Barbara J Sahakian; David K Menon Journal: Brain Date: 2011-02-09 Impact factor: 13.501
Authors: Y Kang; K Jamison; A Jaywant; K Dams-O'Connor; N Kim; N A Karakatsanis; T Butler; N D Schiff; A Kuceyeski; S A Shah Journal: Brain Commun Date: 2022-06-15
Authors: Tsang-Wei Tu; Wael G Ibrahim; Neekita Jikaria; Jeeva P Munasinghe; Jaclyn A Witko; Dima A Hammoud; Joseph A Frank Journal: Sci Rep Date: 2018-01-12 Impact factor: 4.379