PURPOSE: To establish scientific relationship between relative humidity (RH) and aqueous tear evaporation to elucidate possible significance of this relationship in normals and aqueous tear deficiency patients. DESIGN: Prospective experimental laboratory study. METHODS:Ocular surface evaporation was determined using evaporometry and calculated for two ranges of RH, 25% to 35%, and 35% to 45% in a randomized clinical patient population. RESULTS:Average evaporative rate in the higher humidity range was between 0.029 +/- 0.009 through 0.043 +/- 0.016 microl/cm2/min. At lower humidity, range was between 0.044 +/- 0.013 through 0.058 +/- 0.018 microl/cm2/min. Differences in the corresponding evaporative rates were statistically significant (between P < .003 through P < .043) for each analysis. CONCLUSIONS: A decrease of 10% RH resulted in an average difference of between 28.33% to 59.42% increase in evaporation. The increase in evaporation at lower humidity has significant clinical implications for patients with aqueous deficient dry eyes, and possibly those undergoing laser-assisted in situ keratomileusis (LASIK).
RCT Entities:
PURPOSE: To establish scientific relationship between relative humidity (RH) and aqueous tear evaporation to elucidate possible significance of this relationship in normals and aqueous tear deficiencypatients. DESIGN: Prospective experimental laboratory study. METHODS: Ocular surface evaporation was determined using evaporometry and calculated for two ranges of RH, 25% to 35%, and 35% to 45% in a randomized clinical patient population. RESULTS: Average evaporative rate in the higher humidity range was between 0.029 +/- 0.009 through 0.043 +/- 0.016 microl/cm2/min. At lower humidity, range was between 0.044 +/- 0.013 through 0.058 +/- 0.018 microl/cm2/min. Differences in the corresponding evaporative rates were statistically significant (between P < .003 through P < .043) for each analysis. CONCLUSIONS: A decrease of 10% RH resulted in an average difference of between 28.33% to 59.42% increase in evaporation. The increase in evaporation at lower humidity has significant clinical implications for patients with aqueous deficient dry eyes, and possibly those undergoing laser-assisted in situ keratomileusis (LASIK).
Authors: Mark D P Willcox; Pablo Argüeso; Georgi A Georgiev; Juha M Holopainen; Gordon W Laurie; Tom J Millar; Eric B Papas; Jannick P Rolland; Tannin A Schmidt; Ulrike Stahl; Tatiana Suarez; Lakshman N Subbaraman; Omür Ö Uçakhan; Lyndon Jones Journal: Ocul Surf Date: 2017-07-20 Impact factor: 5.033
Authors: Harrison Dermer; Daniella Lent-Schochet; Despoina Theotoka; Christian Paba; Abdullah A Cheema; Ryan S Kim; Anat Galor Journal: Drugs Date: 2020-04 Impact factor: 9.546