PURPOSE: To provide optical characteristics of cotton-wool spots (CWS) on optical coherence tomography (OCT) and scan the retina after CWS have ophthalmoscopically disappeared. DESIGN: Observational case reports. METHODS: We studied four eyes of four patients with retinopathy due to human immunodeficiency virus (HIV) and hypertension. The StratusOCT Model 3000 in single-line mode was used for imaging of acute and resolved CWS and adjacent normal retina. The fundus photography served as a template for OCT scanning in localization of CWS. Retinal tissue reflectivity images were compared. RESULTS: There were differences in reflectivity of normal retina, the retina in the area of active CWS, and the retina in the same area after CWS has resolved. Most striking was that the OCT documented a persistent focal area of hyper-reflectivity in the area of the resolved CWS, indicative of retinal gliosis that could be imaged. CONCLUSIONS: CWS show a hyper-reflective pattern on OCT that persists even after they become ophthalmoscopically invisible.
PURPOSE: To provide optical characteristics of cotton-wool spots (CWS) on optical coherence tomography (OCT) and scan the retina after CWS have ophthalmoscopically disappeared. DESIGN: Observational case reports. METHODS: We studied four eyes of four patients with retinopathy due to human immunodeficiency virus (HIV) and hypertension. The StratusOCT Model 3000 in single-line mode was used for imaging of acute and resolved CWS and adjacent normal retina. The fundus photography served as a template for OCT scanning in localization of CWS. Retinal tissue reflectivity images were compared. RESULTS: There were differences in reflectivity of normal retina, the retina in the area of active CWS, and the retina in the same area after CWS has resolved. Most striking was that the OCT documented a persistent focal area of hyper-reflectivity in the area of the resolved CWS, indicative of retinal gliosis that could be imaged. CONCLUSIONS: CWS show a hyper-reflective pattern on OCT that persists even after they become ophthalmoscopically invisible.
Authors: Michael H Goldbaum; Irina Falkenstein; Igor Kozak; Jiucang Hao; Dirk-Uwe Bartsch; Terrance Sejnowski; William R Freeman Journal: Trans Am Ophthalmol Soc Date: 2008
Authors: Igor Kozak; Pamela A Sample; Jiucang Hao; William R Freeman; Robert N Weinreb; Te-Won Lee; Michael H Goldbaum Journal: Trans Am Ophthalmol Soc Date: 2007
Authors: Michael H Goldbaum; Igor Kozak; Jiucang Hao; Pamela A Sample; TeWon Lee; Igor Grant; William R Freeman Journal: Graefes Arch Clin Exp Ophthalmol Date: 2010-09-24 Impact factor: 3.117