Literature DB >> 16563818

Cardioprotective effects of vegetables: is nitrate the answer?

Jon O Lundberg1, Martin Feelisch, Håkan Björne, Emmelie A Jansson, Eddie Weitzberg.   

Abstract

A diet rich in fruits and vegetables is associated with a lower risk of certain forms of cancer and cardiovascular disease, but the mechanisms behind this protection are not completely understood. Recent epidemiological studies suggest a cardioprotective action afforded specifically by green leafy vegetables. We here propose that these beneficial effects are related to the high content of inorganic nitrate, which in concert with symbiotic bacteria in the oral cavity is converted into nitrite, nitric oxide, and secondary reaction products with vasodilating and tissue-protective properties.

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Year:  2006        PMID: 16563818     DOI: 10.1016/j.niox.2006.01.013

Source DB:  PubMed          Journal:  Nitric Oxide        ISSN: 1089-8603            Impact factor:   4.427


  42 in total

1.  Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.

Authors:  Fadi N Salloum; Gregory R Sturz; Chang Yin; Shabina Rehman; Nicholas N Hoke; Rakesh C Kukreja; Lei Xi
Journal:  Exp Biol Med (Maywood)       Date:  2014-10-30

2.  Visualization of NO3⁻/NO2⁻ Dynamics in Living Cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-component Regulatory System.

Authors:  Masafumi Hidaka; Aina Gotoh; Taiki Shimizu; Kiwamu Minamisawa; Hiromi Imamura; Takafumi Uchida
Journal:  J Biol Chem       Date:  2015-12-02       Impact factor: 5.157

Review 3.  Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

Authors:  Carl D Koch; Mark T Gladwin; Bruce A Freeman; Jon O Lundberg; Eddie Weitzberg; Alison Morris
Journal:  Free Radic Biol Med       Date:  2016-12-16       Impact factor: 7.376

Review 4.  Is nitric oxide a hormone?

Authors:  Asghar Ghasemi; Saleh Zahediasl
Journal:  Iran Biomed J       Date:  2011

Review 5.  Inorganic nitrite therapy: historical perspective and future directions.

Authors:  Christopher G Kevil; Gopi K Kolluru; Christopher B Pattillo; Tony Giordano
Journal:  Free Radic Biol Med       Date:  2011-05-04       Impact factor: 7.376

Review 6.  Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling.

Authors:  Brian S Zuckerbraun; Patricia George; Mark T Gladwin
Journal:  Cardiovasc Res       Date:  2010-12-22       Impact factor: 10.787

Review 7.  Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease.

Authors:  Nathan S Bryan
Journal:  Curr Atheroscler Rep       Date:  2018-03-17       Impact factor: 5.113

Review 8.  Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan.

Authors:  Theodore W Kurtz; Stephen E DiCarlo; Michal Pravenec; R Curtis Morris
Journal:  J Cardiol       Date:  2018-03-12       Impact factor: 3.159

Review 9.  Nitrite as regulator of hypoxic signaling in mammalian physiology.

Authors:  Ernst E van Faassen; Soheyl Bahrami; Martin Feelisch; Neil Hogg; Malte Kelm; Daniel B Kim-Shapiro; Andrey V Kozlov; Haitao Li; Jon O Lundberg; Ron Mason; Hans Nohl; Tienush Rassaf; Alexandre Samouilov; Anny Slama-Schwok; Sruti Shiva; Anatoly F Vanin; Eddie Weitzberg; Jay Zweier; Mark T Gladwin
Journal:  Med Res Rev       Date:  2009-09       Impact factor: 12.944

10.  Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury.

Authors:  Nathan S Bryan; John W Calvert; John W Elrod; Susheel Gundewar; Sang Yong Ji; David J Lefer
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-19       Impact factor: 11.205

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