| Literature DB >> 16563760 |
Stephen Robert Fletcher1, Edward McIver, Stephen Lewis, Frank Burkamp, Clare Leech, Glenn Mason, Susan Boyce, Denise Morrison, Gillian Richards, Kathy Sutton, Anthony Brian Jones.
Abstract
Based on a series of diaryl amides the corresponding inverse amides have been found to be potent TRPV1 receptor antagonists. Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.Entities:
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Year: 2006 PMID： 16563760 DOI： 10.1016/j.bmcl.2006.03.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823