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Literature DB >> 1655945

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.

Abstract

The severe combined immunodeficiency (SCID) mutation has been postulated to affect a V(D)J recombinase activity involved in coding joint formation. Analysis of 38 joints from 34 distinct sequences of normally rearranged T cell receptor (TCR) gamma and delta genes from adult, SCID thymocytes reveals coding joints with an increased number of P nucleotides. One-third of P sequences are greater than or equal to 4 nucleotides in length and P elements of up to 15 bases are observed. This suggests that the SCID defect deregulates P nucleotide addition. Consequently, essential V(D)J recombination intermediates may seldom be generated.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1655945 PMCID： PMC2118963 DOI： 10.1084/jem.174.4.769

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

32 in total

1. Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.

Authors: D M Asarnow; W A Kuziel; M Bonyhadi; R E Tigelaar; P W Tucker; J P Allison
Journal: Cell Date: 1988-12-02 Impact factor: 41.582

2. Mechanisms of nonhomologous recombination in mammalian cells.

Authors: D B Roth; T N Porter; J H Wilson
Journal: Mol Cell Biol Date: 1985-10 Impact factor: 4.272

3. Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

Authors: D B Roth; J H Wilson
Journal: Mol Cell Biol Date: 1986-12 Impact factor: 4.272

4. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Authors: R K Saiki; D H Gelfand; S Stoffel; S J Scharf; R Higuchi; G T Horn; K B Mullis; H A Erlich
Journal: Science Date: 1988-01-29 Impact factor: 47.728

5. Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

Authors: M G Kim; W Schuler; M J Bosma; K B Marcu
Journal: J Immunol Date: 1988-08-15 Impact factor: 5.422

6. T-cell receptor delta gene rearrangements in early thymocytes.

Authors: Y H Chien; M Iwashima; D A Wettstein; K B Kaplan; J F Elliott; W Born; M M Davis
Journal: Nature Date: 1987 Dec 24-31 Impact factor: 49.962

7. The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.

Authors: J F Elliott; E P Rock; P A Patten; M M Davis; Y H Chien
Journal: Nature Date: 1988-02-18 Impact factor: 49.962

8. The scid mutation in mice causes a general defect in DNA repair.

Authors: G M Fulop; R A Phillips
Journal: Nature Date: 1990-10-04 Impact factor: 49.962

9. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

10. Normal T cell development is possible without 'functional' gamma chain genes.

Authors: A Traunecker; F Oliveri; N Allen; K Karjalainen
Journal: EMBO J Date: 1986-07 Impact factor: 11.598

14 in total

1. Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase.

Authors: Leslie E Huye; Mary M Purugganan; Ming-Ming Jiang; David B Roth
Journal: Mol Cell Biol Date: 2002-05 Impact factor: 4.272

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.

1. Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.

2. Mechanisms of nonhomologous recombination in mammalian cells.

3. Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

4. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

5. Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

6. T-cell receptor delta gene rearrangements in early thymocytes.

7. The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.

8. The scid mutation in mice causes a general defect in DNA repair.

9. DNA sequencing with chain-terminating inhibitors.

10. Normal T cell development is possible without 'functional' gamma chain genes.

1. Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase.

2. Nucleotide deletion and P addition in V(D)J recombination: a determinant role of the coding-end sequence.

3. DST4: a new, and probably the last, functional DH gene in the BALB/c mouse.

4. Biased T-cell receptor delta element recombination in scid thymocytes.

5. Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.

Review 6. The response to and repair of RAG-mediated DNA double-strand breaks.

7. Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

8. Diversity of functional T-cell receptor delta-chain transcripts from bone marrow cells of athymic nude mice.

9. scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase.

10. Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes.