BACKGROUND: We assessed the efficacy and safety profile of a docetaxel (Taxotere; Sanofi-Aventis, France), fluorouracil (FU), and leucovorin (LV) combination (TFL), as first-line chemotherapy in patients with advanced gastric cancer. METHODS: Fifty-eight patients with advanced gastric cancer were entered in this phase II study. The chemotherapy regimen (TFL) was administered in an outpatient setting as follows: docetaxel 7 mg/m2 on day 1 and FU 50 mg/m2 and LV 30 mg/m2 on days 1 to 3, every 3 weeks for six cycles. RESULTS: On an intent-to-treat basis, 4 complete (7%) and 11 partial responses (19%) were observed, with an objective overall response rate of 26%; in addition, 22 patients (38%) had stable and 15 (26%) had progressive disease. For 6 (10%) patients, response could not be evaluated. Responses were noted at all metastatic sites. With a median follow-up of 55 months, median survival was 9 months; median time to progression, 5.9 months; and median duration of response, 10 months. Toxicity was manageable and no toxic death was reported. Neutropenia was the most frequent severe toxicity and occurred in 30% of the patients. The main non-hematologic toxicities were alopecia (76%), diarrhea (30%), and stomatitis (30%). CONCLUSION: The results of this phase II study seem to indicate that the TFL regimen has moderate activity in patients with advanced gastric cancer, with acceptable toxicity.
BACKGROUND: We assessed the efficacy and safety profile of a docetaxel (Taxotere; Sanofi-Aventis, France), fluorouracil (FU), and leucovorin (LV) combination (TFL), as first-line chemotherapy in patients with advanced gastric cancer. METHODS: Fifty-eight patients with advanced gastric cancer were entered in this phase II study. The chemotherapy regimen (TFL) was administered in an outpatient setting as follows: docetaxel 7 mg/m2 on day 1 and FU 50 mg/m2 and LV 30 mg/m2 on days 1 to 3, every 3 weeks for six cycles. RESULTS: On an intent-to-treat basis, 4 complete (7%) and 11 partial responses (19%) were observed, with an objective overall response rate of 26%; in addition, 22 patients (38%) had stable and 15 (26%) had progressive disease. For 6 (10%) patients, response could not be evaluated. Responses were noted at all metastatic sites. With a median follow-up of 55 months, median survival was 9 months; median time to progression, 5.9 months; and median duration of response, 10 months. Toxicity was manageable and no toxic death was reported. Neutropenia was the most frequent severe toxicity and occurred in 30% of the patients. The main non-hematologic toxicities were alopecia (76%), diarrhea (30%), and stomatitis (30%). CONCLUSION: The results of this phase II study seem to indicate that the TFL regimen has moderate activity in patients with advanced gastric cancer, with acceptable toxicity.
Authors: C Louvet; A de Gramont; B Demuynck; B Nordlinger; J E Maisani; B Lagadec; S Delfau; C Varette; G Gonzalez-Canali; M Krulik Journal: Ann Oncol Date: 1991-03 Impact factor: 32.976
Authors: S A Cullinan; C G Moertel; T R Fleming; J R Rubin; J E Krook; L K Everson; H E Windschitl; D I Twito; R F Marschke; J F Foley Journal: JAMA Date: 1985-04-12 Impact factor: 56.272
Authors: Peter C Thuss-Patience; Albrecht Kretzschmar; Michael Repp; Dorothea Kingreen; Dirk Hennesser; Simone Micheel; Daniel Pink; Christian Scholz; Bernd Dörken; Peter Reichardt Journal: J Clin Oncol Date: 2005-01-20 Impact factor: 44.544
Authors: J A Wils; H O Klein; D J Wagener; H Bleiberg; H Reis; F Korsten; T Conroy; M Fickers; S Leyvraz; M Buyse Journal: J Clin Oncol Date: 1991-05 Impact factor: 44.544
Authors: U Vanhoefer; P Rougier; H Wilke; M P Ducreux; A J Lacave; E Van Cutsem; M Planker; J G Santos; P Piedbois; B Paillot; H Bodenstein; H J Schmoll; H Bleiberg; B Nordlinger; M L Couvreur; B Baron; J A Wils Journal: J Clin Oncol Date: 2000-07 Impact factor: 44.544
Authors: A D Roth; R Maibach; G Martinelli; N Fazio; M S Aapro; O Pagani; R Morant; M M Borner; R Herrmann; H Honegger; F Cavalli; P Alberto; M Castiglione; A Goldhirsch Journal: Ann Oncol Date: 2000-03 Impact factor: 32.976
Authors: D Kelsen; O T Atiq; L Saltz; D Niedzwiecki; D Ginn; D Chapman; R Heelan; C Lightdale; V Vinciguerra; M Brennan Journal: J Clin Oncol Date: 1992-04 Impact factor: 44.544
Authors: A Sulkes; J Smyth; C Sessa; L Y Dirix; J B Vermorken; S Kaye; J Wanders; H Franklin; N LeBail; J Verweij Journal: Br J Cancer Date: 1994-08 Impact factor: 7.640
Authors: Martin L Ashdown; Andrew P Robinson; Steven L Yatomi-Clarke; M Luisa Ashdown; Andrew Allison; Derek Abbott; Svetomir N Markovic; Brendon J Coventry Journal: F1000Res Date: 2015-07-13