Literature DB >> 16555550

Immunohistochemical detection of apoptotic markers in gastric cancer.

Laura Smith1, Helen K Berrieman, Sara L O'Kane, Anne Campbell, Anthony Maraveyas, Lynn Cawkwell.   

Abstract

Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the proapoptotic proteins Bad, Bak, Bax, Bid, Bim, and p53 in 21 cases of gastric cancer. Immunopositivity was observed in 12/21 (57%) cases for p53, 16/21 (76%) cases for Bcl-XL, and 5/21 (23%) cases for Bcl-2. For the proapoptotic members of the Bcl family, loss of protein expression was observed: Bid (14/21 cases; 66%), Bad (13/21 cases; 61%), Bax (12/21 cases; 57%), Bak (9/21 cases; 42%), and Bim (4/21 cases; 19%). This study identified apoptosis proteins that exhibit heterogeneous expression between primary gastric carcinomas.

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Year:  2006        PMID： 16555550     DOI： 10.3727/096504005776568246

Source DB:  PubMed          Journal:  Oncol Res        ISSN： 0965-0407            Impact factor:   5.574


  7 in total

1.  Differential expression of Bcl-2 and Bax during gastric ischemia-reperfusion of rats.

Authors:  Wei-Li Qiao; Guang-Ming Wang; Yue Shi; Jin-Xia Wu; You-Jian Qi; Jian-Fu Zhang; Hong Sun; Chang-Dong Yan
Journal:  World J Gastroenterol       Date:  2011-04-07       Impact factor: 5.742

2.  The downregulation of Bcl-xL/Bcl-2-associated death promoter indicates worse outcomes in patients with small cell lung carcinoma.

Authors:  Yaoyang Yu; Zhaokui Zhong; Yaowu Guan
Journal:  Int J Clin Exp Pathol       Date:  2015-10-01

3.  Loss of Bad expression confers poor prognosis in non-small cell lung cancer.

Authors:  Yi Huang; Dan Liu; Bojiang Chen; Jing Zeng; Lei Wang; Shangfu Zhang; Xianming Mo; Weimin Li
Journal:  Med Oncol       Date:  2011-09-15       Impact factor: 3.064

4.  Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma.

Authors:  R K Lindemann; A Newbold; K F Whitecross; L A Cluse; A J Frew; L Ellis; S Williams; A P Wiegmans; A E Dear; C L Scott; M Pellegrini; A Wei; V M Richon; Paul A Marks; S W Lowe; M J Smyth; R W Johnstone
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-30       Impact factor: 11.205

5.  Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk.

Authors:  Sue K Park; Jae Jeong Yang; Sohee Oh; Lisa Y Cho; Seung Hyun Ma; Aesun Shin; Kwang-Pil Ko; Taesung Park; Keun-Young Yoo; Daehee Kang
Journal:  PLoS One       Date:  2012-09-21       Impact factor: 3.240

6.  Expression of Bim, Noxa, and Puma in non-small cell lung cancer.

Authors:  Jun Sakakibara-Konishi; Satoshi Oizumi; Junko Kikuchi; Eiki Kikuchi; Hidenori Mizugaki; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Journal:  BMC Cancer       Date:  2012-07-12       Impact factor: 4.430

7.  The expression of Bcl-2 and BID in gastric cancer cells.

Authors:  Mariusz Gryko; Anna Pryczynicz; Konrad Zareba; Bogusław Kędra; Andrzej Kemona; Katarzyna Guzińska-Ustymowicz
Journal:  J Immunol Res       Date:  2014-02-19       Impact factor: 4.818
  7 in total

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