Literature DB >> 1655526

Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit.

W Wisden1, A Herb, H Wieland, K Keinänen, H Lüddens, P H Seeburg.   

Abstract

A cDNA of rat brain encoding the GABAA receptor alpha 4 subunit has been cloned. Recombinant receptors composed of alpha 4, beta 2 and gamma 2 subunit bind with high affinity the GABA agonist [3H]muscimol and the benzodiazepine 'alcohol antagonist' [3H]Ro 15-4513, but fail to bind benzodiazepine agonists. The alpha 4 subunit is expressed mainly in the thalamus, as assessed by in situ hybridization histochemistry, and may participate in a major population of thalamic GABAA receptors. The alpha 4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1655526     DOI： 10.1016/0014-5793(91)81076-k

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  49 in total

1.  Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

Authors:  Brandon M Stell; Stephen G Brickley; C Y Tang; Mark Farrant; Istvan Mody
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

2.  Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

Authors:  K L Hadingham; P C Harkness; R M McKernan; K Quirk; B Le Bourdellès; A L Horne; J A Kemp; E A Barnard; C I Ragan; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

3.  The third gamma subunit of the gamma-aminobutyric acid type A receptor family.

Authors:  A Herb; W Wisden; H Lüddens; G Puia; S Vicini; P H Seeburg
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

4.  Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

Review 5.  Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.

Authors:  H Mohler; F Knoflach; J Paysan; K Motejlek; D Benke; B Lüscher; J M Fritschy
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

Review 6.  The GABAA receptors.

Authors:  F A Stephenson
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

7.  Strain-specific programming of prenatal ethanol exposure across generations.

Authors:  Daniel O Popoola; Michael E Nizhnikov; Nicole M Cameron
Journal:  Alcohol       Date:  2017-01-04       Impact factor: 2.405

Review 8.  The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

Authors:  W Hevers; H Lüddens
Journal:  Mol Neurobiol       Date:  1998-08       Impact factor: 5.590

9.  Nucleus-specific expression of GABA(A) receptor subunit mRNAs in monkey thalamus.

Authors:  M M Huntsman; M G Leggio; E G Jones
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

10.  Forebrain and midbrain distribution of major benzodiazepine-sensitive GABAA receptor subunits in the adult C57 mouse as assessed with in situ hybridization.

Authors:  S A Heldt; K J Ressler
Journal:  Neuroscience       Date:  2007-09-12       Impact factor: 3.590
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.