Literature DB >> 7643969

Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.

H Mohler1, F Knoflach, J Paysan, K Motejlek, D Benke, B Lüscher, J M Fritschy.   

Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinational assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

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Year:  1995        PMID： 7643969     DOI： 10.1007/bf01694546

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  36 in total

1.  Identification of distinct GABAA-receptor subtypes in cholinergic and parvalbumin-positive neurons of the rat and marmoset medial septum-diagonal band complex.

Authors:  B Gao; J P Hornung; J M Fritschy
Journal:  Neuroscience       Date:  1995-03       Impact factor: 3.590

2.  Molecular characterization of type I GABAA receptor complex from rat cerebral cortex and hippocampus.

Authors:  D Ruano; F Araujo; A Machado; A L de Blas; J Vitorica
Journal:  Brain Res Mol Brain Res       Date:  1994-09

3.  BSF1, a novel brain-specific DNA-binding protein recognizing a tandemly repeated purine DNA element in the GABAA receptor delta subunit gene.

Authors:  K Motejlek; R Häuselmann; S Leitgeb; B Lüscher
Journal:  J Biol Chem       Date:  1994-05-27       Impact factor: 5.157

4.  Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study.

Authors:  J M Fritschy; J Paysan; A Enna; H Mohler
Journal:  J Neurosci       Date:  1994-09       Impact factor: 6.167

5.  Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

Authors:  F Knoflach; U Drescher; L Scheurer; P Malherbe; H Mohler
Journal:  J Pharmacol Exp Ther       Date:  1993-07       Impact factor: 4.030

6.  GABAA receptor subunit immunoreactivity in primate visual cortex: distribution in macaques and humans and regulation by visual input in adulthood.

Authors:  S H Hendry; M M Huntsman; A Viñuela; H Möhler; A L de Blas; E G Jones
Journal:  J Neurosci       Date:  1994-04       Impact factor: 6.167

7.  Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.

Authors:  G Puia; I Ducic; S Vicini; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

8.  Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies.

Authors:  J M Fritschy; D Benke; S Mertens; W H Oertel; T Bachi; H Möhler
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

Review 9.  Novel anxiolytics that act as partial agonists at benzodiazepine receptors.

Authors:  W Haefely; J R Martin; P Schoch
Journal:  Trends Pharmacol Sci       Date:  1990-11       Impact factor: 14.819

10.  A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.

Authors:  H A Wieland; H Lüddens; P H Seeburg
Journal:  J Biol Chem       Date:  1992-01-25       Impact factor: 5.157
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  14 in total

Review 1.  Overview--flavonoids: a new family of benzodiazepine receptor ligands.

Authors:  J H Medina; H Viola; C Wolfman; M Marder; C Wasowski; D Calvo; A C Paladini
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

2.  The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function.

Authors:  Andrew J Boileau; Robert A Pearce; Cynthia Czajkowski
Journal:  J Neurosci       Date:  2010-04-07       Impact factor: 6.167

Review 3.  The external globus pallidus: progress and perspectives.

Authors:  Daniel J Hegeman; Ellie S Hong; Vivian M Hernández; C Savio Chan
Journal:  Eur J Neurosci       Date:  2016-03-28       Impact factor: 3.386

Review 4.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

Review 5.  GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.

Authors:  Herve Le-Corronc; Jean-Michel Rigo; Pascal Branchereau; Pascal Legendre
Journal:  Mol Neurobiol       Date:  2011-05-06       Impact factor: 5.590

6.  Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  2000-12       Impact factor: 3.996

7.  Inhibitory plasticity dictates the sign of plasticity at excitatory synapses.

Authors:  Lang Wang; Arianna Maffei
Journal:  J Neurosci       Date:  2014-01-22       Impact factor: 6.167

8.  Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein.

Authors:  Andrew J Boileau; Robert A Pearce; Cynthia Czajkowski
Journal:  J Neurosci       Date:  2005-12-07       Impact factor: 6.167

9.  Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Authors:  U Günther; J Benson; D Benke; J M Fritschy; G Reyes; F Knoflach; F Crestani; A Aguzzi; M Arigoni; Y Lang; H Bluethmann; H Mohler; B Lüscher
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

10.  Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism.

Authors:  A Oblak; T T Gibbs; G J Blatt
Journal:  Autism Res       Date:  2009-08       Impact factor: 5.216
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