Literature DB >> 16552483

Phospholipase and proteinase activities of clinical isolates of Candida from immunocompromised patients.

C P Girish Kumar1, S Suresh Jothi Kumar, Thangam Menon.   

Abstract

Sixty-one isolates of Candida recovered from HIV seropositive and cancer patients were studied for elaboration of putative virulence determinants--phospholipase (PL) and secreted aspartyl proteinase (Sap). Forty two (68.85%) isolates examined were PL producers and 51 (83.6%) were positive for Sap. 57.37% (35/61) isolates produced both enzymes. Enzymatic activity was more pronounced in Candida albicans with 100% PL and 94.1% Sap activity. In contrast, non-C. albicans species demonstrated only 29.6% PL and 70.3% Sap activity, indicating interplay of other virulence determinants in these yeasts in colonization and disease.

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Year:  2006        PMID： 16552483     DOI： 10.1007/s11046-005-0157-4

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


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  21 in total

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Journal:  Mycopathologia       Date:  2018-11-30       Impact factor: 2.574

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Authors:  Sukumaran Anil; Mohamed Hashem; Sajith Vellappally; Shankargouda Patil; H M H N Bandara; L P Samaranayake
Journal:  Mycopathologia       Date:  2014-08-21       Impact factor: 2.574

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Journal:  Mycopathologia       Date:  2008-09-12       Impact factor: 2.574

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Journal:  Clin Oral Investig       Date:  2015-07-30       Impact factor: 3.573
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