Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.

Literature DB >> 16543219

The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.

Michael-Christopher Keogh¹, Thomas A Mennella, Chika Sawa, Sharon Berthelet, Nevan J Krogan, Adam Wolek, Vladimir Podolny, Laura Rocco Carpenter, Jack F Greenblatt, Kristin Baetz, Stephen Buratowski.

Abstract

The histone H2A variant H2A.Z (Saccharomyces cerevisiae Htz1) plays roles in transcription, DNA repair, chromosome stability, and limiting telomeric silencing. The Swr1-Complex (SWR-C) inserts Htz1 into chromatin and shares several subunits with the NuA4 histone acetyltransferase. Furthermore, mutants of these two complexes share several phenotypes, suggesting they may work together. Here we show that NuA4 acetylates Htz1 Lys 14 (K14) after the histone is assembled into chromatin by the SWR-C. K14 mutants exhibit specific defects in chromosome transmission without affecting transcription, telomeric silencing, or DNA repair. Function-specific modifications may help explain how the same component of chromatin can function in diverse pathways.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16543219 PMCID： PMC1413285 DOI： 10.1101/gad.1388106

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

40 in total

1. Histone acetyltransferases: preparation of substrates and assay procedures.

Authors: C A Mizzen; J E Brownell; R G Cook; C D Allis
Journal: Methods Enzymol Date: 1999 Impact factor: 1.600

2. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.

Authors: Vivien Measday; Kristin Baetz; Julie Guzzo; Karen Yuen; Teresa Kwok; Bilal Sheikh; Huiming Ding; Ryo Ueta; Trinh Hoac; Benjamin Cheng; Isabelle Pot; Amy Tong; Yuko Yamaguchi-Iwai; Charles Boone; Phil Hieter; Brenda Andrews
Journal: Proc Natl Acad Sci U S A Date: 2005-09-19 Impact factor: 11.205

3. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.

Authors: Ryan M Raisner; Paul D Hartley; Marc D Meneghini; Marie Z Bao; Chih Long Liu; Stuart L Schreiber; Oliver J Rando; Hiten D Madhani
Journal: Cell Date: 2005-10-21 Impact factor: 41.582

4. A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission.

Authors: M M Smith; P Yang; M S Santisteban; P W Boone; A T Goldstein; P C Megee
Journal: Mol Cell Biol Date: 1996-03 Impact factor: 4.272

5. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

Authors: S Allard; R T Utley; J Savard; A Clarke; P Grant; C J Brandl; L Pillus; J L Workman; J Côté
Journal: EMBO J Date: 1999-09-15 Impact factor: 11.598

6. ESA1 is a histone acetyltransferase that is essential for growth in yeast.

Authors: E R Smith; A Eisen; W Gu; M Sattah; A Pannuti; J Zhou; R G Cook; J C Lucchesi; C D Allis
Journal: Proc Natl Acad Sci U S A Date: 1998-03-31 Impact factor: 11.205

7. Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability.

Authors: A M Carr; S M Dorrington; J Hindley; G A Phear; S J Aves; P Nurse
Journal: Mol Gen Genet Date: 1994-12-01

8. Cse4p is a component of the core centromere of Saccharomyces cerevisiae.

Authors: P B Meluh; P Yang; L Glowczewski; D Koshland; M M Smith
Journal: Cell Date: 1998-09-04 Impact factor: 41.582

9. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

Authors: Gaku Mizuguchi; Xuetong Shen; Joe Landry; Wei-Hua Wu; Subhojit Sen; Carl Wu
Journal: Science Date: 2003-11-26 Impact factor: 47.728

10. The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.

Authors: Kimberley Bruce; Fiona A Myers; Evangelia Mantouvalou; Pascal Lefevre; Ian Greaves; Constanze Bonifer; David J Tremethick; Alan W Thorne; Colyn Crane-Robinson
Journal: Nucleic Acids Res Date: 2005-10-04 Impact factor: 16.971

130 in total

1. Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombe.

Authors: Lei Xiong; Yinsheng Wang
Journal: Int J Mass Spectrom Date: 2011-03-30 Impact factor: 1.986

Review 2. Reading chromatin: insights from yeast into YEATS domain structure and function.

Authors: Julia M Schulze; Alice Y Wang; Michael S Kobor
Journal: Epigenetics Date: 2010-10-01 Impact factor: 4.528

3. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.

Authors: Mohammed Altaf; Andréanne Auger; Julie Monnet-Saksouk; Joëlle Brodeur; Sandra Piquet; Myriam Cramet; Nathalie Bouchard; Nicolas Lacoste; Rhea T Utley; Luc Gaudreau; Jacques Côté
Journal: J Biol Chem Date: 2010-03-23 Impact factor: 5.157

The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.

1. Histone acetyltransferases: preparation of substrates and assay procedures.

2. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.

3. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.

4. A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission.

5. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

6. ESA1 is a histone acetyltransferase that is essential for growth in yeast.

7. Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability.

8. Cse4p is a component of the core centromere of Saccharomyces cerevisiae.

9. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

10. The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.

1. Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombe.

Review 2. Reading chromatin: insights from yeast into YEATS domain structure and function.

3. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.

4. Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions.

5. Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression.

Review 6. Chromatin remodeling and repair of DNA double-strand breaks.

Review 7. Mechanisms of ATP dependent chromatin remodeling.

Review 8. Chromatin dynamics: interplay between remodeling enzymes and histone modifications.

9. Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109.

10. Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.