| Literature DB >> 165427 |
S Muthukrishnan, G W Both, Y Furuichi, A J Shatkin.
Abstract
Unmethylated reovirus and VSV mRNAs are specifically methylated to form 5'-terminal structures of the type, m-7-G(5')ppp(5')N by protein synthesising extracts prepared from wheat germ and mouse L cells. Reticulocyte mRNA also contains 5'-terminal m-7-G. MRNAs having 5'-terminal m-7-G stimulate protein synthesis in vitro. Removal of m-7-G by beta-elimination abolishes translation of the mRNAs.Entities:
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Year: 1975 PMID： 165427 DOI： 10.1038/255033a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962