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Literature DB >> 16541210

[The apoptosis marker enzyme poly-(ADP-ribose) polymerase (PARP) in systemic lupus erythematosus].

Abstract

The enzyme poly-(ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair. During programmed cell death (apoptosis), PARP is enzymatically cleaved. Detection of the cleavage products is characteristic for apoptosis. In patients with systemic lupus erythematosus (SLE), the highly ordered signal transduction cascade of apoptosis is disturbed. SLE patients show reduced PARP activity . PARP cleavage products are mainly found in association with either antinuclear and/or anti-dsDNA antibodies. In addition, serum samples from SLE patients and other autoimmune diseases display anti-PAR and anti-PARP autoantibodies.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16541210 DOI： 10.1007/s00393-006-0045-4

Source DB: PubMed Journal: Z Rheumatol ISSN： 0340-1855 Impact factor: 1.372

44 in total

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Journal: Mol Cell Biochem Date: 1999-09 Impact factor: 3.396

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Journal: J Clin Invest Date: 1999-04 Impact factor: 14.808

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Journal: Mol Cell Biochem Date: 1998-01 Impact factor: 3.396

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Authors: P Decker; D Isenberg; S Muller
Journal: J Biol Chem Date: 2000-03-24 Impact factor: 5.157

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Journal: Arthritis Rheum Date: 1999-10

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Journal: Immunol Lett Date: 1988-05 Impact factor: 3.685

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Authors: P M Gaffney; G M Kearns; K B Shark; W A Ortmann; S A Selby; M L Malmgren; K E Rohlf; T C Ockenden; R P Messner; R A King; S S Rich; T W Behrens
Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

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Journal: Arthritis Rheum Date: 1989-08

10. Identification of autoantibody against poly (ADP-ribose) polymerase (PARP) fragment as a serological marker in systemic lupus erythematosus.

Authors: Dooil Jeoung; Yoon Lim; Eun Bong Lee; Seongeun Lee; Hae-Yeong Kim; Hansoo Lee; Yeong Wook Song
Journal: J Autoimmun Date: 2004-02 Impact factor: 7.094

4 in total