| Literature DB >> 16537118 |
Laurence Faivre1, Jörg Meerpohl, Lydie Da Costa, Isabelle Marie, Christian Nouvel, Astrid Gnekow, Christine Bender-Götze, Francis Bauters, Bertand Coiffier, Pierre-Yves Peaud, Patrick Rispal, Alain Berrebi, Claire Berger, Michel Flesch, Paul Sagot, Bruno Varet, Charlotte Niemeyer, Gil Tchernia, Thierry Leblanc.
Abstract
We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.Entities:
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Year: 2006 PMID： 16537118
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941