INTRODUCTION: The observation of an increasing number of methicillin-resistant Staphylococcus aureus (MRSA) isolated from children prompted us to study the microbiological, epidemiological and clinical characteristics of these isolates. The possibility of some of them being community-acquired focused particularly our attention. METHODS: A retrospective analysis of all children with MRSA isolated at the Doce de Octubre hospital between January 2002 and June 2005 was conducted. Infections were classified as community-acquired, hospital-acquired, or health-care associated. Isolates of MRSA were studied by pulsed-field gel electrophoresis (PFGE) and SSCmec typing. The presence of the gene encoding the Panton-Valentine leukocidin was also detected by PCR. RESULTS: MRSA were isolated from 17 patients. Seven isolates (42.2%) were community-acquired, corresponding to four cases of skin or soft-tissue infections, two otitis cases and one bacteremic pyomyositis. Six of seven community-acquired isolates had the same ECP pattern (genotype D), presented a type IV SSCmec, and were LPV toxin-producing and methicillin-resistant with no other associated resistances. CONCLUSION: To our knowledge, this study shows the presence of these community-acquired MRSA strains for the first time in Spain. The evidence of an apparently clonal spreading of community-acquired MRSA infections in children has important implications for public health and treatment strategies.
INTRODUCTION: The observation of an increasing number of methicillin-resistant Staphylococcus aureus (MRSA) isolated from children prompted us to study the microbiological, epidemiological and clinical characteristics of these isolates. The possibility of some of them being community-acquired focused particularly our attention. METHODS: A retrospective analysis of all children with MRSA isolated at the Doce de Octubre hospital between January 2002 and June 2005 was conducted. Infections were classified as community-acquired, hospital-acquired, or health-care associated. Isolates of MRSA were studied by pulsed-field gel electrophoresis (PFGE) and SSCmec typing. The presence of the gene encoding the Panton-Valentine leukocidin was also detected by PCR. RESULTS: MRSA were isolated from 17 patients. Seven isolates (42.2%) were community-acquired, corresponding to four cases of skin or soft-tissue infections, two otitis cases and one bacteremic pyomyositis. Six of seven community-acquired isolates had the same ECP pattern (genotype D), presented a type IV SSCmec, and were LPV toxin-producing and methicillin-resistant with no other associated resistances. CONCLUSION: To our knowledge, this study shows the presence of these community-acquired MRSA strains for the first time in Spain. The evidence of an apparently clonal spreading of community-acquired MRSA infections in children has important implications for public health and treatment strategies.
Authors: I Niniou; S Vourli; E Lebessi; M Foustoukou; A Vatopoulos; D G Pasparakis; D A Kafetzis; M N Tsolia Journal: Eur J Clin Microbiol Infect Dis Date: 2008-06-07 Impact factor: 3.267
Authors: Teresa del Rosal; Fernando Baquero-Artigao; Cristina Calvo; María J Mellado; Juan C Molina; María del Mar Santos; María J Cilleruelo; Mercedes Bueno; Pilar Storch de Gracia; Covadonga Terol; Miguel Á Roa; Roi Piñeiro; Milagros García López-Hortelano; María L García-García; Sonia Rodríguez; María Penín; Alejandro Zarauza; Francisco Alvarado; Ana de Blas; Enrique Otheo; Alfonso Rodríguez; María L Herreros; Alfredo Tagarro; Luis Grande; José T Ramos; Irene Maté; Cristina Muñoz; Miguel Á Zafra; María P Romero-Gómez; Elia Pérez-Fernández; Alberto Delgado; Inmaculada Casas; María E Cabezas Journal: Influenza Other Respir Viruses Date: 2011-07-22 Impact factor: 4.380
Authors: Teresa Del Rosal; Ana Méndez-Echevarría; Cesar Garcia-Vera; Luis Escosa-Garcia; Martin Agud; Fernando Chaves; Federico Román; José Gutierrez-Fernandez; Enrique Ruiz de Gopegui; Guillermo Ruiz-Carrascoso; Maria Del Carmen Ruiz-Gallego; Albert Bernet; Sara Maria Quevedo; Ana Maria Fernández-Verdugo; Jesús Díez-Sebastian; Cristina Calvo Journal: Infect Drug Resist Date: 2020-12-23 Impact factor: 4.003
Authors: Federico Román; Ana Mendez-Echevarria; Teresa Del Rosal; Cesar Garcia-Vera; Luis Escosa-Garcia; Martin Agud; Fernando Chaves; José Gutiérrez-Fernández; Enrique Ruiz de Gopegui; Guillermo Ruiz-Carrascoso; Maria Del Carmen Ruiz-Gallego; Albert Bernet; Sara Maria Quevedo; Ana Maria Fernández-Verdugo; Talia Sainz; Cristina Calvo Journal: Microbiologyopen Date: 2021-10 Impact factor: 3.139
Authors: Laura B Nellums; Hayley Thompson; Alison Holmes; Enrique Castro-Sánchez; Jonathan A Otter; Marie Norredam; Jon S Friedland; Sally Hargreaves Journal: Lancet Infect Dis Date: 2018-05-17 Impact factor: 71.421