Literature DB >> 16532006

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Paul Erbel1, Nikolaus Schiering, Allan D'Arcy, Martin Renatus, Markus Kroemer, Siew Pheng Lim, Zheng Yin, Thomas H Keller, Subhash G Vasudevan, Ulrich Hommel.   

Abstract

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.

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Year:  2006        PMID： 16532006     DOI： 10.1038/nsmb1073

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  171 in total

1.  The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.

Authors:  Sergey A Shiryaev; Andrei V Chernov; Tatiana N Shiryaeva; Alexander E Aleshin; Alex Y Strongin
Journal:  Arch Virol       Date:  2010-10-27       Impact factor: 2.574

2.  Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.

Authors:  Sergey A Shiryaev; Alex Y Strongin
Journal:  Future Virol       Date:  2010-09-01       Impact factor: 1.831

3.  Anthracene-based inhibitors of dengue virus NS2B-NS3 protease.

Authors:  Suzanne M Tomlinson; Stanley J Watowich
Journal:  Antiviral Res       Date:  2010-12-23       Impact factor: 5.970

4.  Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Authors:  Sergey A Shiryaev; Boris I Ratnikov; Alexander E Aleshin; Igor A Kozlov; Nicholas A Nelson; Michal Lebl; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Journal:  J Virol       Date:  2007-02-14       Impact factor: 5.103

5.  Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution.

Authors:  Thai Leong Yap; Ting Xu; Yen-Liang Chen; Helene Malet; Marie-Pierre Egloff; Bruno Canard; Subhash G Vasudevan; Julien Lescar
Journal:  J Virol       Date:  2007-02-14       Impact factor: 5.103

6.  Crystal structure of the NS3 protease-helicase from dengue virus.

Authors:  Dahai Luo; Ting Xu; Cornelia Hunke; Gerhard Grüber; Subhash G Vasudevan; Julien Lescar
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103

Review 7.  The expanding diversity of serine hydrolases.

Authors:  Istvan Botos; Alexander Wlodawer
Journal:  Curr Opin Struct Biol       Date:  2007-09-24       Impact factor: 6.809

8.  Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors.

Authors:  Szymon Pach; Tim M Sarter; Rafe Yousef; David Schaller; Silke Bergemann; Christoph Arkona; Jörg Rademann; Christoph Nitsche; Gerhard Wolber
Journal:  ACS Med Chem Lett       Date:  2020-03-03       Impact factor: 4.345

9.  Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viral replication.

Authors:  Fan Jia; Jingjing Fan; Bo Zhang; Zhiming Yuan
Journal:  Virol Sin       Date:  2013-01-16       Impact factor: 4.327

10.  Antiviral cationic peptides as a strategy for innovation in global health therapeutics for dengue virus: high yield production of the biologically active recombinant plectasin peptide.

Authors:  Hussin A Rothan; Zulqarnain Mohamed; Abdulrazzaq M Suhaeb; Noorsaadah Abd Rahman; Rohana Yusof
Journal:  OMICS       Date:  2013-09-17
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