| Literature DB >> 16530035 |
Abstract
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.Entities:
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Year: 2006 PMID： 16530035 DOI： 10.1016/j.cell.2006.02.029
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582