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Literature DB >> 20159562

BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.

Zihua Gong¹, Ja-Eun Kim, Charles Chung Yun Leung, J N Mark Glover, Junjie Chen.

Abstract

Human TopBP1 plays a critical role in the control of DNA replication checkpoint. In this study, we report a specific interaction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks. The TopBP1/BACH1 interaction is mediated by the very C-terminal tandem BRCT domains of TopBP1 and S phase-specific phosphorylation of BACH1 at Thr 1133 site. Interestingly, we demonstrate that depletion of TopBP1 or BACH1 attenuates the loading of RPA on chromatin. Moreover, both TopBP1 and BACH1 are required for ATR-dependent phosphorylation events in response to replication stress. Taken together, our data suggest that BACH1 has an unexpected early role in replication checkpoint control. A specific interaction between TopBP1 and BACH1 is likely to be required for the extension of single-stranded DNA regions and RPA loading following replication stress, which is a prerequisite for the subsequent activation of replication checkpoint.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2010 PMID： 20159562 PMCID： PMC3695484 DOI： 10.1016/j.molcel.2010.01.002

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

34 in total

1. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation.

Authors: P Nghiem; P K Park; Y Kim ; C Vaziri; S L Schreiber
Journal: Proc Natl Acad Sci U S A Date: 2001-07-31 Impact factor: 11.205

2. BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.

Authors: M Mäkiniemi; T Hillukkala; J Tuusa; K Reini; M Vaara; D Huang; H Pospiech; I Majuri; T Westerling; T P Mäkelä; J E Syväoja
Journal: J Biol Chem Date: 2001-06-06 Impact factor: 5.157

3. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.

Authors: Xiaochun Yu; Junjie Chen
Journal: Mol Cell Biol Date: 2004-11 Impact factor: 4.272

4. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

Authors: Kazuhiko Yamane; Xianglin Wu; Junjie Chen
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

5. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.

Authors: H Wang; S J Elledge
Journal: Proc Natl Acad Sci U S A Date: 1999-03-30 Impact factor: 11.205

10. Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.

Authors: Manhong Guo; Venkatasubramanian Vidhyasagar; Hao Ding; Yuliang Wu
Journal: J Biol Chem Date: 2014-02-25 Impact factor: 5.157

BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.

1. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation.

2. BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.

3. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.

4. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

5. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.

6. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

7. BRCT repeats as phosphopeptide-binding modules involved in protein targeting.

8. The BRCT domain is a phospho-protein binding domain.

9. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

10. The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.

1. TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

2. BRCA1 is required for postreplication repair after UV-induced DNA damage.

3. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control.

Review 4. BRCT domains: easy as one, two, three.

5. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.

6. BLM's balancing act and the involvement of FANCJ in DNA repair.

7. FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses.

8. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.

9. Chk1 suppressed cell death.

10. Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.