Literature DB >> 16528853

Occupational exposure to hexavalent chromium. Final rule.

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Abstract

The Occupational Safety and Health Administration (OSHA) is amending the existing standard which limits occupational exposure to hexavalent chromium (Cr(VI)). OSHA has determined based upon the best evidence currently available that at the current permissible exposure limit (PEL) for Cr(VI), workers face a significant risk to material impairment of their health. The evidence in the record for this rulemaking indicates that workers exposed to Cr(VI) are at an increased risk of developing lung cancer. The record also indicates that occupational exposure to Cr(VI) may result in asthma, and damage to the nasal epithelia and skin. The final rule establishes an 8-hour time-weighted average (TWA) exposure limit of 5 micrograms of Cr(VI) per cubic meter of air (5 [mu]g/cu m). This is a considerable reduction from the previous PEL of 1 milligram per 10 cubic meters of air (1 mg/10 cu m, or 100 [mu]g/cu m) reported as CrO3, which is equivalent to a limit of 52 [mu]g/cu m as Cr(VI). The final rule also contains ancillary provisions for worker protection such as requirements for exposure determination, preferred exposure control methods, including a compliance alternative for a small sector for which the new PEL is infeasible, respiratory protection, protective clothing and equipment, hygiene areas and practices, medical surveillance, recordkeeping, and start-up dates that include four years for the implementation of engineering controls to meet the PEL. The final standard separately regulates general industry, construction, and shipyards in order to tailor requirements to the unique circumstances found in each of these sectors. The PEL established by this rule reduces the significant risk posed to workers by occupational exposure to Cr(VI) to the maximum extent that is technologically and economically feasible.

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Year:  2006        PMID: 16528853

Source DB:  PubMed          Journal:  Fed Regist        ISSN: 0097-6326


  32 in total

Review 1.  Influence of welding fume metal composition on lung toxicity and tumor formation in experimental animal models.

Authors:  Patti C Zeidler-Erdely; Lauryn M Falcone; James M Antonini
Journal:  J Occup Environ Hyg       Date:  2019-04-01       Impact factor: 2.155

2.  Re: Seidler A, Jänichen S, Hegewald J et al. Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium.

Authors:  B Pesch; T Weiss; D Pallapies; G Schlüter; T Brüning
Journal:  Int Arch Occup Environ Health       Date:  2013-05-28       Impact factor: 3.015

3.  The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.

Authors:  Young-Ok Son; John Andrew Hitron; Senping Cheng; Amit Budhraja; Zhuo Zhang; Nancy Lan Guo; Jeong-Chae Lee; Xianglin Shi
Journal:  Toxicol Sci       Date:  2010-11-03       Impact factor: 4.849

4.  Modelling of occupational exposure to inhalable nickel compounds.

Authors:  Benjamin Kendzia; Beate Pesch; Dorothea Koppisch; Rainer Van Gelder; Katrin Pitzke; Wolfgang Zschiesche; Thomas Behrens; Tobias Weiss; Jack Siemiatycki; Jerome Lavoué; Karl-Heinz Jöckel; Roger Stamm; Thomas Brüning
Journal:  J Expo Sci Environ Epidemiol       Date:  2017-01-18       Impact factor: 5.563

Review 5.  Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies.

Authors:  Natalie H Matthews; Katherine Fitch; Wen-Qing Li; J Steven Morris; David C Christiani; Abrar A Qureshi; Eunyoung Cho
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2018-10-08       Impact factor: 4.254

6.  Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.

Authors:  Mindy F Reynolds; Elizabeth C Peterson-Roth; Ivan A Bespalov; Tatiana Johnston; Volkan M Gurel; Haley L Menard; Anatoly Zhitkovich
Journal:  Cancer Res       Date:  2009-01-13       Impact factor: 12.701

7.  Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring.

Authors:  Jone A Stanley; Kirthiram K Sivakumar; Joe A Arosh; Robert C Burghardt; Sakhila K Banu
Journal:  Biol Reprod       Date:  2014-05-07       Impact factor: 4.285

8.  Reduction in welding fume and metal exposure of stainless steel welders: an example from the WELDOX study.

Authors:  Martin Lehnert; Tobias Weiss; Beate Pesch; Anne Lotz; Sandra Zilch-Schöneweis; Evelyn Heinze; Rainer Van Gelder; Jens-Uwe Hahn; Thomas Brüning
Journal:  Int Arch Occup Environ Health       Date:  2013-05-30       Impact factor: 3.015

9.  Chromium VI - Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins.

Authors:  Sakhila K Banu; Jone A Stanley; Kirthiram K Sivakumar; Joe A Arosh; Robert J Taylor; Robert C Burghardt
Journal:  Reprod Toxicol       Date:  2016-07-18       Impact factor: 3.143

Review 10.  Occupational and environmental causes of lung cancer.

Authors:  R William Field; Brian L Withers
Journal:  Clin Chest Med       Date:  2012-12       Impact factor: 2.878

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