| Literature DB >> 16528056 |
Olivier Andréoletti1, Nathalie Morel2, Caroline Lacroux1, Virginie Rouillon1, Céline Barc3, Guillaume Tabouret1, Pierre Sarradin3, Patricia Berthon3, Philippe Bernardet3, Jacinthe Mathey1, Séverine Lugan1, Pierrette Costes1, Fabien Corbière1, Juan-Carlos Espinosa4, Juan Maria Torres4, Jacques Grassi2, François Schelcher1, Frédéric Lantier3.
Abstract
Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrP(Sc) in the spleen.Entities:
Mesh：
Year: 2006 PMID： 16528056 DOI： 10.1099/vir.0.81318-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891