Literature DB >> 16524284

An improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol.

Ralf J Kloetzing1, Tobias Thaler, Paul Knochel.   

Abstract

[reaction: see text] (-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.

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Year:  2006        PMID： 16524284     DOI： 10.1021/ol0531381

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Optimized Synthesis of a Pentafluoro-gem-diol and Conversion to a CF2Br-Glucopyranose through Trifluoroacetate-Release and Halogenation.

Authors:  Robert A Hazlitt; Jinu P John; Que-Lynn Tran; David A Colby
Journal:  Tetrahedron Lett       Date:  2016-03-19       Impact factor: 2.415

2.  Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide.

Authors:  Robert M Demoret; Meghan A Baker; Masaki Ohtawa; Shuming Chen; Ching Ching Lam; Sophia Khom; Marisa Roberto; Stefano Forli; Kendall N Houk; Ryan A Shenvi
Journal:  J Am Chem Soc       Date:  2020-10-16       Impact factor: 15.419
  2 in total

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