Literature DB >> 16522788

Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans.

Chantal A A van der Graaf1, Mihai G Netea, Barbara Franke, Stephen E Girardin, Jos W M van der Meer, Bart Jan Kullberg.   

Abstract

Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.

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Year:  2006        PMID： 16522788      PMCID： PMC1391959          DOI： 10.1128/CVI.13.3.423-425.2006

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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