| Literature DB >> 25714264 |
Nan-Xin Zheng1, Yan Wang, Dan-Dan Hu, Lan Yan, Yuan-Ying Jiang.
Abstract
Candida albicans is both a commensal microorganism in healthy individuals and a major fungal pathogen causing high mortality in immunocompromised patients. Yeast-hypha morphological transition is a well known virulence trait of C. albicans. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs). In this review, we summarize the PRRs involved in the recognition of C. albicans in epithelial cells, endothelial cells, and phagocytic cells separately. We figure out the differential recognition of yeasts and hyphae, the findings on PRR-deficient mice, and the discoveries on human PRR-related single nucleotide polymorphisms (SNPs).Entities:
Keywords: Candida albicans; epithelial cells; innate immunity; pattern recognition receptors; phagocytic cells
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Year: 2015 PMID: 25714264 PMCID: PMC4601294 DOI: 10.1080/21505594.2015.1014270
Source DB: PubMed Journal: Virulence ISSN: 2150-5594 Impact factor: 5.882