Literature DB >> 25714264

The role of pattern recognition receptors in the innate recognition of Candida albicans.

Nan-Xin Zheng1, Yan Wang, Dan-Dan Hu, Lan Yan, Yuan-Ying Jiang.   

Abstract

Candida albicans is both a commensal microorganism in healthy individuals and a major fungal pathogen causing high mortality in immunocompromised patients. Yeast-hypha morphological transition is a well known virulence trait of C. albicans. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs). In this review, we summarize the PRRs involved in the recognition of C. albicans in epithelial cells, endothelial cells, and phagocytic cells separately. We figure out the differential recognition of yeasts and hyphae, the findings on PRR-deficient mice, and the discoveries on human PRR-related single nucleotide polymorphisms (SNPs).

Entities:  

Keywords:  Candida albicans; epithelial cells; innate immunity; pattern recognition receptors; phagocytic cells

Mesh:

Substances:

Year:  2015        PMID: 25714264      PMCID: PMC4601294          DOI: 10.1080/21505594.2015.1014270

Source DB:  PubMed          Journal:  Virulence        ISSN: 2150-5594            Impact factor:   5.882


  199 in total

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