OBJECTIVE: Do repeat prenatal corticosteroids suppress neonatal cortisol concentrations? STUDY DESIGN: Randomized controlled trial of women given weeklyrepeat corticosteroids or saline placebo, while at risk of preterm birth, until 32 weeks' gestation. RESULTS:Cord serum cortisol concentrations in infants exposed to repeat corticosteroids were similar compared with infants exposed to a single course of corticosteroids (mean difference -26 nmol/L (95% CI -57, 5 nmol/L, P = .10), as were prestress salivary cortisol concentrations on day 3 (median 16.5 vs 15.3 nmol/L, P = .96). The adrenal response to a stressor on day 3 was lower in the repeat corticosteroid group compared with the single course group (median 11.9 vs 21.4 nmol/L, P = .02). Cortisol concentrations were lower in the repeat corticosteroid group on day 7 (median 11.7 vs 18.2 nmol/L, P = .04), but not on days 14 and 21. CONCLUSION: The short- or long-term clinical impact, if any, of these changes in adrenal function needs to be determined.
RCT Entities:
OBJECTIVE: Do repeat prenatal corticosteroids suppress neonatal cortisol concentrations? STUDY DESIGN: Randomized controlled trial of women given weekly repeat corticosteroids or saline placebo, while at risk of preterm birth, until 32 weeks' gestation. RESULTS: Cord serum cortisol concentrations in infants exposed to repeat corticosteroids were similar compared with infants exposed to a single course of corticosteroids (mean difference -26 nmol/L (95% CI -57, 5 nmol/L, P = .10), as were prestress salivary cortisol concentrations on day 3 (median 16.5 vs 15.3 nmol/L, P = .96). The adrenal response to a stressor on day 3 was lower in the repeat corticosteroid group compared with the single course group (median 11.9 vs 21.4 nmol/L, P = .02). Cortisol concentrations were lower in the repeat corticosteroid group on day 7 (median 11.7 vs 18.2 nmol/L, P = .04), but not on days 14 and 21. CONCLUSION: The short- or long-term clinical impact, if any, of these changes in adrenal function needs to be determined.
Authors: Seung Mi Lee; Roberto Romero; Jeong Woo Park; Sun Min Kim; Chan-Wook Park; Steven J Korzeniewski; Tinnakorn Chaiworapongsa; Bo Hyun Yoon Journal: J Matern Fetal Neonatal Med Date: 2012-04-25
Authors: Mai Thanh Tu; Ruth E Grunau; Julie Petrie-Thomas; David W Haley; Joanne Weinberg; Michael F Whitfield Journal: Dev Psychobiol Date: 2007-03 Impact factor: 3.038
Authors: Augusto F Schmidt; Matthew W Kemp; Judith Rittenschober-Böhm; Paranthaman S Kannan; Haruo Usuda; Masatoshi Saito; Lucy Furfaro; Shimpei Watanabe; Sarah Stock; Boris W Kramer; John P Newnham; Suhas G Kallapur; Alan H Jobe Journal: Am J Obstet Gynecol Date: 2017-11-11 Impact factor: 8.661