| Literature DB >> 16517161 |
Xiaoxia Qian1, Gui-Bai Liang, Dennis Feng, Michael Fisher, Tami Crumley, Sandra Rattray, Paula M Dulski, Anne Gurnett, Penny Sue Leavitt, Paul A Liberator, Andrew S Misura, Samantha Samaras, Tamas Tamas, Dennis M Schmatz, Matthew Wyvratt, Tesfaye Biftu.
Abstract
2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.Entities:
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Year: 2006 PMID： 16517161 DOI： 10.1016/j.bmcl.2006.01.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823