| Literature DB >> 16516891 |
Seung-Hun Kim1, Hee-Ju Park, Chang-Min Lee, Il-Whan Choi, Dong-Oh Moon, Hwan-Jung Roh, Hern-Ku Lee, Yeong-Min Park.
Abstract
Epigallocatechin-3-gallate (EGCG), a major form of tea catechin, has anti-allergic properties. To elucidate the anti-allergic mechanisms of EGCG, we investigated its regulation of matrix metalloproteinase (MMP-9) expression in toluene diisocyanate (TDI)-inhalation lung tissues as well as TNF-alpha and Th2 cytokine (IL-5) production in BAL fluid. Compared with untreated asthmatic mice those administrated with EGCG had significantly reduced asthmatic reaction. Also, increased reactive oxygen species (ROS) generation by TDI inhalation was diminished by administration of EGCG in BAL fluid. These results suggest that EGCG regulates inflammatory cell migration possibly by suppressing MMP-9 production and ROS generation, and indicate that EGCG may be useful as an adjuvant therapy for bronchial asthma.Entities:
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Year: 2006 PMID： 16516891 DOI： 10.1016/j.febslet.2006.02.052
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124