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Literature DB >> 16516203

Fibroblast growth factor signaling in embryonic and cancer stem cells.

Petr Dvorak¹, Dana Dvorakova, Ales Hampl.

Abstract

Cancer stem cells are cancer cells that originate from the transformation of normal stem cells. The most important property of any stem cell is the ability to self-renew. Through this property, there are striking parallels between normal stem cells and cancer stem cells. Both cell types share various markers of "stemness". In particular, normal stem cells and cancer stem cells utilize similar molecular mechanisms to drive self-renewal, and similar signaling pathways may induce their differentiation. The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.

Entities: Disease Gene Species

Mesh：

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Year: 2006 PMID： 16516203 DOI： 10.1016/j.febslet.2006.01.095

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

37 in total

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2. Angiogenesis-independent tumor growth mediated by stem-like cancer cells.

Authors: Per Ø Sakariassen; Lars Prestegarden; Jian Wang; Kai-Ove Skaftnesmo; Rupavathana Mahesparan; Carla Molthoff; Peter Sminia; Eirik Sundlisaeter; Anjan Misra; Berit Bølge Tysnes; Martha Chekenya; Hans Peters; Gabriel Lende; Karl Henning Kalland; Anne M Øyan; Kjell Petersen; Inge Jonassen; Albert van der Kogel; Burt G Feuerstein; A Jorge A Terzis; Rolf Bjerkvig; Per Øyvind Enger
Journal: Proc Natl Acad Sci U S A Date: 2006-10-20 Impact factor: 11.205

3. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.

Authors: Israel S Fernández; Pedro Cuevas; Javier Angulo; Pilar López-Navajas; Angeles Canales-Mayordomo; Rocío González-Corrochano; Rosa M Lozano; Serafín Valverde; Jesús Jiménez-Barbero; Antonio Romero; Guillermo Giménez-Gallego
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Review 4. Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.

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5. Axin2 expression identifies progenitor cells in the murine prostate.

Authors: Christopher S Ontiveros; Sarah N Salm; E Lynette Wilson
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6. Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

Authors: Takeshi Shimizu; Tetsushi Kagawa; Toshihiro Inoue; Aya Nonaka; Shinji Takada; Hiroyuki Aburatani; Tetsuya Taga
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Fibroblast growth factor signaling in embryonic and cancer stem cells.

1. DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas.

2. Angiogenesis-independent tumor growth mediated by stem-like cancer cells.

3. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.

Review 4. Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.

5. Axin2 expression identifies progenitor cells in the murine prostate.

6. Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

Review 7. High molecular weight FGF2: the biology of a nuclear growth factor.

8. Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell.

9. Multicell simulations of development and disease using the CompuCell3D simulation environment.

10. Niche-mediated control of human embryonic stem cell self-renewal and differentiation.