| Literature DB >> 23863198 |
Abstract
Non-canonical cytoplasmic activities and signal transduction of retinoic acid (RA) expand RA's pleiotropic effects in coordinating the epigenome in embryonic stem cell (ESC). Examples include RA-bound cellular retinoic acid binding protein I, which activates ERK2. By engaging both cytosolic and nuclear mediators, RA can efficiently augment ESC's epigenome.Entities:
Keywords: CRABPI; ERK; OCT4; TR2; embryonic stem cell; epigenetic; retinoic acid
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Year: 2013 PMID: 23863198 PMCID: PMC3977914 DOI: 10.4161/trns.25395
Source DB: PubMed Journal: Transcription ISSN: 2154-1272