Literature DB >> 16515820

Rat genetics: the next episode.

Bart M G Smits1, Edwin Cuppen.   

Abstract

More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.

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Year:  2006        PMID： 16515820     DOI： 10.1016/j.tig.2006.02.009

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  4 in total

1.  Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.

Authors:  Zoltán Ivics; Zsuzsanna Izsvák; Gerardo Medrano; Karen M Chapman; F Kent Hamra
Journal:  Nat Protoc       Date:  2011-09-08       Impact factor: 13.491

2.  Multiplex microsatellite marker panels for genetic monitoring of common rat strains.

Authors:  Elizabeth C Bryda; Lela K Riley
Journal:  J Am Assoc Lab Anim Sci       Date:  2008-05       Impact factor: 1.232

Review 3.  Gene targeting in the rat: advances and opportunities.

Authors:  Howard J Jacob; Jozef Lazar; Melinda R Dwinell; Carol Moreno; Aron M Geurts
Journal:  Trends Genet       Date:  2010-10-01       Impact factor: 11.639

4.  Phylogeny and biogeography of African Murinae based on mitochondrial and nuclear gene sequences, with a new tribal classification of the subfamily.

Authors:  Emilie Lecompte; Ken Aplin; Christiane Denys; François Catzeflis; Marion Chades; Pascale Chevret
Journal:  BMC Evol Biol       Date:  2008-07-10       Impact factor: 3.260
  4 in total

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