OBJECTIVE: To analyze the effectiveness of methotrexate (MTX) for the therapy of pediatric localized scleroderma (LS). METHODS: A retrospective chart review was performed for 17 pediatric patients with LS who failed topical therapy and were subsequently treated with MTX (12.5-25 mg weekly) with or without oral corticosteroids. A structured followup telephone call to the families was used to assess patient satisfaction. RESULTS: Skin findings improved in 16 of 17 patients with a median time to improvement of 2.25 and 2.0 months for MTX alone or in combination with corticosteroids. Only one patient had active lesions at the most recent followup visit. Fifteen of 17 families reported improvement in their child's lesions after beginning MTX. Twelve of 17 patients were treated with MTX and oral corticosteroids. There were no major adverse events. CONCLUSION: MTX appears to be a safe and effective therapy for pediatric LS.
OBJECTIVE: To analyze the effectiveness of methotrexate (MTX) for the therapy of pediatric localized scleroderma (LS). METHODS: A retrospective chart review was performed for 17 pediatric patients with LS who failed topical therapy and were subsequently treated with MTX (12.5-25 mg weekly) with or without oral corticosteroids. A structured followup telephone call to the families was used to assess patient satisfaction. RESULTS: Skin findings improved in 16 of 17 patients with a median time to improvement of 2.25 and 2.0 months for MTX alone or in combination with corticosteroids. Only one patient had active lesions at the most recent followup visit. Fifteen of 17 families reported improvement in their child's lesions after beginning MTX. Twelve of 17 patients were treated with MTX and oral corticosteroids. There were no major adverse events. CONCLUSION:MTX appears to be a safe and effective therapy for pediatric LS.
Authors: Suzanne C Li; Kathryn S Torok; Elena Pope; Fatma Dedeoglu; Sandy Hong; Heidi T Jacobe; C Egla Rabinovich; Ronald M Laxer; Gloria C Higgins; Polly J Ferguson; Andrew Lasky; Kevin Baszis; Mara Becker; Sarah Campillo; Victoria Cartwright; Michael Cidon; Christi J Inman; Rita Jerath; Kathleen M O'Neil; Sheetal Vora; Andrew Zeft; Carol A Wallace; Norman T Ilowite; Robert C Fuhlbrigge Journal: Arthritis Care Res (Hoboken) Date: 2012-08 Impact factor: 4.794
Authors: Megan Arthur; Nicole M Fett; Emile Latour; Heidi Jacobe; Elaine Kunzler; Stephanie Florez-Pollack; Jacob Houser; Shivani Sharma; Smriti Prasad; Alisa Femia; Marleigh J Stern; Lisa K Pappas-Taffer; Rebecca Gaffney; Anthony P Fernandez; Daniel Knabel; Adela Rambi Cardones; Nicole Leung; Anne Laumann; Jeong Min Yu; Jeffrey Zhao; Ruth Ann Vleugels; Elizabeth Tkachenko; Kelly Lo Journal: JAMA Dermatol Date: 2020-05-01 Impact factor: 10.282
Authors: Jorre S Mertens; Marieke M B Seyger; Rogier M Thurlings; Timothy R D J Radstake; Elke M G J de Jong Journal: Am J Clin Dermatol Date: 2017-08 Impact factor: 7.403