Literature DB >> 16506694

Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.

Fumitaka Kudo1, Yasuhito Yamamoto, Kenichi Yokoyama, Tadashi Eguchi, Katsumi Kakinuma.   

Abstract

NeoA, B, and C encoded in the neomycin biosynthetic gene cluster have been enzymatically confirmed to be responsible to the formation of 2-deoxystreptamine (DOS) in Streptomyces fradiae. NeoC was functionally characterized as 2-deoxy-scyllo-inosose synthase, which catalyzes the carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose. Further, NeoA appeared to catalyze the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(P)+ forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI). Consequently, NeoA was characterized as 2-deoxy-scyllo-inosamine dehydrogenase. Finally, amino-DOI produced by NeoA from DOIA was transformed into DOS by NeoB. Since NeoB (Neo6) was also reported to be L-glutamine:2-deoxy-scyllo-inosose aminotransferase, all the enzymes in the DOS biosynthesis were characterized for the first time.

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Year:  2005        PMID： 16506694     DOI： 10.1038/ja.2005.104

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.

Authors:  Je Won Park; Sung Ryeol Park; Keshav Kumar Nepal; Ah Reum Han; Yeon Hee Ban; Young Ji Yoo; Eun Ji Kim; Eui Min Kim; Dooil Kim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Nat Chem Biol       Date:  2011-10-09       Impact factor: 15.040

2.  The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin.

Authors:  Garrett T Dow; James B Thoden; Hazel M Holden
Journal:  Protein Sci       Date:  2018-04-02       Impact factor: 6.725

Review 3.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

Review 4.  Radical SAM enzymes in the biosynthesis of sugar-containing natural products.

Authors:  Mark W Ruszczycky; Yasushi Ogasawara; Hung-Wen Liu
Journal:  Biochim Biophys Acta       Date:  2011-12-07

5.  X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.

Authors:  Peter J Goldman; Tyler L Grove; Squire J Booker; Catherine L Drennan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-18       Impact factor: 11.205

Review 6.  Progress in aminocyclitol biosynthesis.

Authors:  Taifo Mahmud
Journal:  Curr Opin Chem Biol       Date:  2009-03-25       Impact factor: 8.822

7.  Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.

Authors:  Je Won Park; Jay Sung Joong Hong; Niranjan Parajuli; Won Seok Jung; Sung Ryeol Park; Si-Kyu Lim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-12       Impact factor: 11.205

Review 8.  Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily.

Authors:  B Persson; J Hedlund; H Jörnvall
Journal:  Cell Mol Life Sci       Date:  2008-12       Impact factor: 9.261

9.  Alteration of the Canine Metabolome After a 3-Week Supplementation of Cannabidiol (CBD) Containing Treats: An Exploratory Study of Healthy Animals.

Authors:  Elizabeth M Morris; Susanna E Kitts-Morgan; Dawn M Spangler; Ibukun M Ogunade; Kyle R McLeod; David L Harmon
Journal:  Front Vet Sci       Date:  2021-07-16
  9 in total

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