OBJECTIVES: To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection. STUDY DESIGN: Cases of syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis. RESULTS: Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm, P = 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm and -0.261 RNA log10 copies/ml, P = 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same. CONCLUSION: Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis.
OBJECTIVES: To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection. STUDY DESIGN: Cases of syphilis diagnosed during 1 year in HIV-infectedpatients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis. RESULTS: Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm, P = 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm and -0.261 RNA log10 copies/ml, P = 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same. CONCLUSION: Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis.
Authors: Maraya de Jesus Semblano Bittencourt; Arival Cardoso de Brito; Bianca Angelina Macêdo do Nascimento; Alessandra Haber Carvalho; Manoel Dias do Nascimento Journal: An Bras Dermatol Date: 2015 May-Jun Impact factor: 1.896
Authors: Diane M Janowicz; Klara Tenner-Racz; Paul Racz; Tricia L Humphreys; Carol Schnizlein-Bick; Kate R Fortney; Beth Zwickl; Barry P Katz; James J Campbell; David D Ho; Stanley M Spinola Journal: J Infect Dis Date: 2007-04-05 Impact factor: 5.226
Authors: Cynthia W Baffi; Inmaculada Aban; James H Willig; Mayank Agrawal; Michael J Mugavero; Laura H Bachmann Journal: AIDS Patient Care STDS Date: 2010-01 Impact factor: 5.078
Authors: Noah Kiwanuka; Merlin Robb; Oliver Laeyendecker; Godfrey Kigozi; Fred Wabwire-Mangen; Fredrick E Makumbi; Fred Nalugoda; Joseph Kagaayi; Michael Eller; Leigh Anne Eller; David Serwadda; Nelson K Sewankambo; Steven J Reynolds; Thomas C Quinn; Ronald H Gray; Maria J Wawer; Christopher C Whalen Journal: J Acquir Immune Defic Syndr Date: 2010-06 Impact factor: 3.731
Authors: Christine L Mattson; Heather Bradley; Linda Beer; Christopher Johnson; William S Pearson; R Luke Shouse Journal: Clin Infect Dis Date: 2017-03-01 Impact factor: 9.079
Authors: Joseph C Forbi; Grace Pennap; Arthur Obinyelaku; Odunayo Iperepolu; Simon Agwale Journal: J Health Popul Nutr Date: 2009-10 Impact factor: 2.000