Literature DB >> 16505319

PCV chemotherapy for recurrent glioblastoma.

F Schmidt1, J Fischer, U Herrlinger, K Dietz, J Dichgans, M Weller.   

Abstract

The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization grade III/IV hematologic toxicity was common (25.6%), but nonhematologic toxicity was mild.

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Year:  2006        PMID: 16505319     DOI: 10.1212/01.wnl.0000197792.73656.c2

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  32 in total

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7.  Procarbazine, carmustine, and vincristine (PBV) for chemotherapy pre-treated patients with recurrent glioblastoma: a single-institution analysis.

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Review 8.  Treating recurrent glioblastoma: an update.

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9.  ACNU-based chemotherapy for recurrent glioma in the temozolomide era.

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