Literature DB >> 26477024

Strategies to target drugs to gliomas and CNS metastases of solid tumors.

B Milojkovic Kerklaan1,2, O van Tellingen3, A D R Huitema4, J H Beijnen4,5, W Boogerd6, J H M Schellens7,8,5, D Brandsma9.   

Abstract

The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood-brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

Entities:  

Keywords:  Antibodies; Brain metastases; Glioma; Nanoparticles; Polymer-based nanocarriers; siRNA

Mesh：

Substances：

Year:  2015        PMID： 26477024     DOI： 10.1007/s00415-015-7919-9

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  125 in total

Review 1.  Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium.

Authors:  Melissa L Bondy; Michael E Scheurer; Beatrice Malmer; Jill S Barnholtz-Sloan; Faith G Davis; Dora Il'yasova; Carol Kruchko; Bridget J McCarthy; Preetha Rajaraman; Judith A Schwartzbaum; Siegal Sadetzki; Brigitte Schlehofer; Tarik Tihan; Joseph L Wiemels; Margaret Wrensch; Patricia A Buffler
Journal:  Cancer       Date:  2008-10-01       Impact factor: 6.860

Review 2.  Transporters of the blood-brain and blood-CSF interfaces in development and in the adult.

Authors:  Norman R Saunders; Richard Daneman; Katarzyna M Dziegielewska; Shane A Liddelow
Journal:  Mol Aspects Med       Date:  2013 Apr-Jun

3.  Brain-targeted delivery of docetaxel by glutathione-coated nanoparticles for brain cancer.

Authors:  Aditya Grover; Anjali Hirani; Yashwant Pathak; Vijaykumar Sutariya
Journal:  AAPS PharmSciTech       Date:  2014-08-19       Impact factor: 3.246

Review 4.  Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.

Authors:  Rashid Deane; Berislav V Zlokovic
Journal:  Curr Alzheimer Res       Date:  2007-04       Impact factor: 3.498

5.  Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.

Authors:  Wolfgang Wick; Vinay K Puduvalli; Marc C Chamberlain; Martin J van den Bent; Antoine F Carpentier; Lawrence M Cher; Warren Mason; Michael Weller; Shengyan Hong; Luna Musib; Astra M Liepa; Donald E Thornton; Howard A Fine
Journal:  J Clin Oncol       Date:  2010-02-01       Impact factor: 44.544

6.  Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.

Authors:  Gregory Cairncross; Meihua Wang; Edward Shaw; Robert Jenkins; David Brachman; Jan Buckner; Karen Fink; Luis Souhami; Normand Laperriere; Walter Curran; Minesh Mehta
Journal:  J Clin Oncol       Date:  2012-10-15       Impact factor: 44.544

7.  Phase I study of GRN1005 in recurrent malignant glioma.

Authors:  Jan Drappatz; Andrew Brenner; Eric T Wong; April Eichler; David Schiff; Morris D Groves; Tom Mikkelsen; Steve Rosenfeld; John Sarantopoulos; Christina A Meyers; Robert M Fielding; Kelly Elian; Xiaolin Wang; Betty Lawrence; Mona Shing; Stephen Kelsey; Jean Paul Castaigne; Patrick Y Wen
Journal:  Clin Cancer Res       Date:  2013-01-24       Impact factor: 12.531

8.  Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat.

Authors:  R Kannan; J F Kuhlenkamp; E Jeandidier; H Trinh; M Ookhtens; N Kaplowitz
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

Review 9.  Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells.

Authors:  Christine Dufès; Majed Al Robaian; Sukrut Somani
Journal:  Ther Deliv       Date:  2013-05

10.  LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease.

Authors:  Carlos Spuch; Saida Ortolano; Carmen Navarro
Journal:  Front Physiol       Date:  2012-07-16       Impact factor: 4.566
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  1 in total

Review 1.  Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context.

Authors:  Jodi M Saunus; Amy E McCart Reed; Zhun Leong Lim; Sunil R Lakhani
Journal:  Int J Mol Sci       Date:  2017-01-13       Impact factor: 5.923
  1 in total

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