BACKGROUND: To assess the incidence of diabetes among sub-groups of the population defined by the presence of one or more simple risk factors, and to investigate population stratification as a means of identifying groups at high risk of diabetes. METHODS: Data from EPIC-Norfolk (1993-1998), a population-based cohort study of 24,714 men and women aged 40-78 years without self-reported diabetes at baseline, were analyzed. During 12 years of follow-up, 608 new cases of diabetes were recorded. RESULTS: Age (RR 1.03; 95% CI 1.02, 1.04), parental history of diabetes (RR 2.15; 95% CI 1.80, 2.57), BMI (RR 1.76; 95% CI 1.53, 2.02) and physical activity (RR 0.72-0.77 (reference sedentary)) were independently related to risk of diabetes. Sedentary, obese individuals aged over 55 years, with a parental history of diabetes were 18 times more likely to develop diabetes than those in the lowest risk group. CONCLUSION: Sedentary, obese men and women over 55 years with a parental history of diabetes form a readily identifiable group, which could be targeted for screening and primary prevention. Groups such as that defined by physical inactivity alone would be more suitable for population level approaches.
BACKGROUND: To assess the incidence of diabetes among sub-groups of the population defined by the presence of one or more simple risk factors, and to investigate population stratification as a means of identifying groups at high risk of diabetes. METHODS: Data from EPIC-Norfolk (1993-1998), a population-based cohort study of 24,714 men and women aged 40-78 years without self-reported diabetes at baseline, were analyzed. During 12 years of follow-up, 608 new cases of diabetes were recorded. RESULTS: Age (RR 1.03; 95% CI 1.02, 1.04), parental history of diabetes (RR 2.15; 95% CI 1.80, 2.57), BMI (RR 1.76; 95% CI 1.53, 2.02) and physical activity (RR 0.72-0.77 (reference sedentary)) were independently related to risk of diabetes. Sedentary, obese individuals aged over 55 years, with a parental history of diabetes were 18 times more likely to develop diabetes than those in the lowest risk group. CONCLUSION: Sedentary, obese men and women over 55 years with a parental history of diabetes form a readily identifiable group, which could be targeted for screening and primary prevention. Groups such as that defined by physical inactivity alone would be more suitable for population level approaches.
Authors: Dara M Shearer; W Murray Thomson; Avshalom Caspi; Terrie E Moffitt; Jonathan M Broadbent; Richie Poulton Journal: Community Dent Oral Epidemiol Date: 2011-10-24 Impact factor: 3.383
Authors: Mauricio Krause; Josianne Rodrigues-Krause; Ciara O'Hagan; Paul Medlow; Gareth Davison; Davide Susta; Colin Boreham; Philip Newsholme; Mark O'Donnell; Colin Murphy; Giuseppe De Vito Journal: Eur J Appl Physiol Date: 2014-02 Impact factor: 3.078
Authors: Janice L Thompson; Peg Allen; Deborah L Helitzer; Clifford Qualls; Ayn N Whyte; Venita K Wolfe; Carla J Herman Journal: Am J Prev Med Date: 2008-03 Impact factor: 5.043
Authors: Juma M Alkaabi; Fatima Al-Maskari; Bachar Afandi; Said Yousef; Syed M Shah; Wieke H Heideman; Emmanuel A Papadimitropoulos; Taoufik Zoubeidi; Abdul-Kader Souid; Marília Silva Paulo; Frank J Snoek Journal: Oman Med J Date: 2021-05-31