OBJECTIVE: To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS). METHODS: We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS. RESULTS: The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results. INTERPRETATION: We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.
OBJECTIVE: To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS). METHODS: We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS. RESULTS: The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results. INTERPRETATION: We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.
Authors: Vey Hadinoto; Michael Shapiro; Thomas C Greenough; John L Sullivan; Katherine Luzuriaga; David A Thorley-Lawson Journal: Blood Date: 2007-11-08 Impact factor: 22.113
Authors: Leena Suleiman; Emmanuelle Waubant; Gregory Aaen; Anita Belman; Leslie Benson; Meghan Candee; Tanuja Chitnis; Mark Gorman; Manu Goyal; Benjamin Greenberg; Yolanda Harris; Janace Hart; Ilana Kahn; Lauren Krupp; Timothy Lotze; Soe Mar; Manikum Moodley; Jayne Ness; Bardia Nourbakhsh; Mary Rensel; Moses Rodriguez; John Rose; Jennifer Rubin; Teri Schreiner; Jan-Mendelt Tillema; Amy Waldman; Bianca Weinstock-Guttman; T Charles Casper; Michael Waltz; Jennifer S Graves Journal: Mult Scler Relat Disord Date: 2018-03-26 Impact factor: 4.339