Mohammed Nizar G Battikhi1, Hussein Ismail, Qusey Battikhi. 1. Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan. nizar@hu.edu.jc
Abstract
BACKGROUND: Prostatic-specific antigen (PSA), a tumor marker helpful in the diagnosis and follow-up of prostate cancer, may rise due to causes such as prostatitis, chronic benign prostatic hyperplasia (BHP), etc. The aim of this study was to investigate the relationship between prostatitis and the level of total and free prostate-specific antigen in patients with no clinical evidence of prostate cancer. METHODS: A comprehensive urological examination was performed on 156 patients aged 35-61 years old. All patients have symptoms of prostatitis. Prostate fluid culture was preformed. All patients underwent a course of antibacterial treatment after which the levels of total prostate specific antigen (TPSA) and free prostate specific antigen (FPSA) were evaluated. RESULTS: An increase in TPSA (> 4 ng/ml) was observed in 14/24 (58.3%) patients with acute prostatitis and in 7/45 (15.5%) and 4/44 (9.1%) in patients with chronic bacterial prostatitis (CBP) and a bacterial prostatitis, respectively. Low blood concentration of TPSA and FPSA were observed after effective antibacterial and anti-inflammatory treatment therapy in most cases. CONCLUSION: These data suggested that prostatitis must be considered when interpretation of TPSA and FPSA values as tumor marker.
BACKGROUND:Prostatic-specific antigen (PSA), a tumor marker helpful in the diagnosis and follow-up of prostate cancer, may rise due to causes such as prostatitis, chronic benign prostatic hyperplasia (BHP), etc. The aim of this study was to investigate the relationship between prostatitis and the level of total and free prostate-specific antigen in patients with no clinical evidence of prostate cancer. METHODS: A comprehensive urological examination was performed on 156 patients aged 35-61 years old. All patients have symptoms of prostatitis. Prostate fluid culture was preformed. All patients underwent a course of antibacterial treatment after which the levels of total prostate specific antigen (TPSA) and free prostate specific antigen (FPSA) were evaluated. RESULTS: An increase in TPSA (> 4 ng/ml) was observed in 14/24 (58.3%) patients with acute prostatitis and in 7/45 (15.5%) and 4/44 (9.1%) in patients with chronic bacterial prostatitis (CBP) and a bacterial prostatitis, respectively. Low blood concentration of TPSA and FPSA were observed after effective antibacterial and anti-inflammatory treatment therapy in most cases. CONCLUSION: These data suggested that prostatitis must be considered when interpretation of TPSA and FPSA values as tumor marker.
Authors: M S Litwin; M McNaughton-Collins; F J Fowler; J C Nickel; E A Calhoun; M A Pontari; R B Alexander; J T Farrar; M P O'Leary Journal: J Urol Date: 1999-08 Impact factor: 7.450
Authors: S J Jacobsen; S K Katusic; E J Bergstralh; J E Oesterling; D Ohrt; G G Klee; C G Chute; M M Lieber Journal: JAMA Date: 1995-11-08 Impact factor: 56.272
Authors: Bettina Schlick; Petra Massoner; Angelika Lueking; Pornpimol Charoentong; Mirjam Blattner; Georg Schaefer; Klaus Marquart; Carmen Theek; Peter Amersdorfer; Dirk Zielinski; Matthias Kirchner; Zlatko Trajanoski; Mark A Rubin; Stefan Müllner; Peter Schulz-Knappe; Helmut Klocker Journal: PLoS One Date: 2016-02-10 Impact factor: 3.240