| Literature DB >> 16497558 |
Debasish Chattopadhyay1, Julian Rayner, Amy M McHenry, John H Adams.
Abstract
Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface. Comparison with Plasmodium reichenowi EBA175 indicates that these interactions have a pivotal role in the host-specific adaptations of parasite ligands.Entities:
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Year: 2006 PMID: 16497558 PMCID: PMC2771403 DOI: 10.1016/j.pt.2006.02.007
Source DB: PubMed Journal: Trends Parasitol ISSN: 1471-4922