Literature DB >> 16494466

Design and synthesis of pyrankacin: a pyranmycin class of broad-spectrum aminoglycoside antibiotic.

Ravi Rai1, Hsiao-Nung Chen, Przemyslaw G Czyryca, Jie Li, Cheng-Wei Tom Chang.   

Abstract

A novel broad-spectrum aminoglycoside antibiotic, pyrankacin, has been prepared. In addition to the synthetic innovation in dideoxygenation and regioselective Staudinger reduction, we have obtained prominent antibacterial activity against several clinically important pathogens in the course of this work.

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Year:  2006        PMID： 16494466     DOI： 10.1021/ol0529750

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Chem Soc Rev       Date:  2018-02-19       Impact factor: 54.564

Review 2.  Antifungal amphiphilic kanamycins: new life for an old drug.

Authors:  Yagya Prasad Subedi; Madher N AlFindee; Jon Y Takemoto; Cheng-Wei Tom Chang
Journal:  Medchemcomm       Date:  2018-04-17       Impact factor: 3.597

3.  2-Deoxystreptamine Conjugates by Truncation-Derivatization of Neomycin.

Authors:  M Waqar Aslam; Leandro C Tabares; Alessio Andreoni; Gerard W Canters; Floris P J T Rutjes; Floris L Van Delft
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-15

Review 4.  Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors.

Authors:  Sandra G Zárate; M Luisa De la Cruz Claure; Raúl Benito-Arenas; Julia Revuelta; Andrés G Santana; Agatha Bastida
Journal:  Molecules       Date:  2018-01-30       Impact factor: 4.411
  4 in total

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