OBJECTIVE: The authors had for aim to evaluate the clinical and immunological response as well as the tolerance to antiretroviral therapy in HIV-2 infected patients. DESIGN: A retrospective chart review was made from August 1998 to August 2004. RESULTS: 188 patients were on protease inhibitor based regimen. 153 (81.38%) were HIV-1 and 35 (18.62%) HIV-2 infected patients. The mean weight gain was significantly higher in the HIV-2 group at months 9 and 12 (P=0.02 et P=0.01 respectively), whereas CD4 cells count gain was higher in the HIV-1 group at month 6 (P=0.004). New AIDS defining criteria are less likely to occur in HIV-2 infected patients on HAART than in HIV-1 (P=0.004). Lipodystrophy syndrome was present only in HIV-1 infected patients. CONCLUSION: Antiretroviral therapy in HIV-2 infected patients shows similar clinical and immunological efficacy than in HIV-1 infected ones and is also well tolerated.
OBJECTIVE: The authors had for aim to evaluate the clinical and immunological response as well as the tolerance to antiretroviral therapy in HIV-2 infectedpatients. DESIGN: A retrospective chart review was made from August 1998 to August 2004. RESULTS: 188 patients were on protease inhibitor based regimen. 153 (81.38%) were HIV-1 and 35 (18.62%) HIV-2 infectedpatients. The mean weight gain was significantly higher in the HIV-2 group at months 9 and 12 (P=0.02 et P=0.01 respectively), whereas CD4 cells count gain was higher in the HIV-1 group at month 6 (P=0.004). New AIDS defining criteria are less likely to occur in HIV-2 infectedpatients on HAART than in HIV-1 (P=0.004). Lipodystrophy syndrome was present only in HIV-1 infectedpatients. CONCLUSION: Antiretroviral therapy in HIV-2 infectedpatients shows similar clinical and immunological efficacy than in HIV-1 infected ones and is also well tolerated.
Authors: Geoffrey S Gottlieb; Ndeye Mery Dia Badiane; Stephen E Hawes; Louise Fortes; Macoumba Toure; Cheikh T Ndour; Alison K Starling; Fatou Traore; Fatima Sall; Kim G Wong; Stephen L Cherne; Donovan J Anderson; Stefanie A Dye; Robert A Smith; James I Mullins; Nancy B Kiviat; Papa Salif Sow Journal: Clin Infect Dis Date: 2009-02-15 Impact factor: 9.079
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Authors: Selly Ba; Ndeye Mery Dia-Badiane; Stephen Edward Hawes; Louise Fortes Deguenonvo; Fatima Sall; Cheikh Tidiane Ndour; Khadim Faye; Fatou Traoré; Macoumba Touré; Marie Pierre Sy; Dana Noelle Raugi; Nancy Berenice Kiviat; Robert Alexander Smith; Moussa Seydi; Papa Salif Sow; Geoffrey Scott Gottlieb Journal: Pan Afr Med J Date: 2019-07-18
Authors: Geoffrey S Gottlieb; Serge-Paul Eholié; John N Nkengasong; Sabelle Jallow; Sarah Rowland-Jones; Hilton C Whittle; Papa Salif Sow Journal: AIDS Date: 2008-10-18 Impact factor: 4.177