| Literature DB >> 16480819 |
Angelo B M Cunha1, Benicio N Frey, Ana C Andreazza, Júlia D Goi, Adriane R Rosa, Carlos A Gonçalves, Aida Santin, Flavio Kapczinski.
Abstract
Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.Entities:
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Year: 2006 PMID： 16480819 DOI： 10.1016/j.neulet.2005.12.085
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046